Estimating kinetic parameters from dynamic contrast‐enhanced t1‐weighted MRI of a diffusable tracer: Standardized quantities and symbols
PS Tofts, G Brix, DL Buckley… - Journal of Magnetic …, 1999 - Wiley Online Library
… Buckley and coworkers have measured pharmacokinetic parameters in the breast (31)
and prostate (32). Henderson and coworkers measured F , PS , and vb in canine mammary …
and prostate (32). Henderson and coworkers measured F , PS , and vb in canine mammary …
[HTML][HTML] Imaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …
used daily in oncology include clinical TNM stage, objective response and left ventricular …
Classic models for dynamic contrast‐enhanced MRI
SP Sourbron, DL Buckley - NMR in Biomedicine, 2013 - Wiley Online Library
Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T 1 ‐weighted
MR images are acquired dynamically after bolus injection of a contrast agent. The data …
MR images are acquired dynamically after bolus injection of a contrast agent. The data …
Phthalimide conjugation as a strategy for in vivo target protein degradation
The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because many …
notably transcription factors, is a particularly challenging problem. In part, this is because many …
Catalytic in vivo protein knockdown by small-molecule PROTACs
…, AH Miah, KE Mulholland, N Routly, DL Buckley… - Nature chemical …, 2015 - nature.com
The current predominant therapeutic paradigm is based on maximizing drug-receptor
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive drug …
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive drug …
[PDF][PDF] YY1 is a structural regulator of enhancer-promoter loops
There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …
control, but we have limited understanding of the proteins that contribute to structural …
Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRI
…, S Cheung, DL Buckley… - … in Medicine: An …, 2006 - Wiley Online Library
Rapid T 1 ‐weighted 3D spoiled gradient‐echo (GRE) data sets were acquired in the
abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast‐…
abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast‐…
The dTAG system for immediate and target-specific protein degradation
Dissection of complex biological systems requires target-specific control of the function or
abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent …
abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent …
Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction
DL Buckley, I Van Molle, PC Gareiss… - Journal of the …, 2012 - ACS Publications
E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and
subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. …
subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. …
Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability
SP Sourbron, DL Buckley - Physics in Medicine & Biology, 2011 - iopscience.iop.org
The tracer-kinetic models developed in the early 1990s for dynamic contrast-enhanced MRI
(DCE-MRI) have since become a standard in numerous applications. At the same time, the …
(DCE-MRI) have since become a standard in numerous applications. At the same time, the …