… Buckley and coworkers have measured pharmacokinetic parameters in the breast (31)
and prostate (32). Henderson and coworkers measured F , PS , and vb in canine mammary …

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Dynamic contrast‐enhanced MRI (DCE‐MRI) is a functional MRI method where T 1 ‐weighted
MR images are acquired dynamically after bolus injection of a contrast agent. The data …

The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because many …

The current predominant therapeutic paradigm is based on maximizing drug-receptor
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive drug …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

Rapid T 1 ‐weighted 3D spoiled gradient‐echo (GRE) data sets were acquired in the
abdomen of 23 cancer patients during a total of 113 separate visits to allow dynamic contrast‐…

Dissection of complex biological systems requires target-specific control of the function or
abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent …

E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and
subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. …

The tracer-kinetic models developed in the early 1990s for dynamic contrast-enhanced MRI
(DCE-MRI) have since become a standard in numerous applications. At the same time, the …