No treatment currently exists to restore lost neurological function after stroke. A growing
number of studies highlight the potential of stem cell transplantation as a novel therapeutic …

Arteriovenous malformations of the brain are congenital vascular lesions that affect 0·01–0·50%
of the population, and are generally present in patients aged 20–40 years. The usual …

We characterize the survival, migration, and differentiation of human neurospheres derived
from CNS stem cells transplanted into the ischemic cortex of rats 7 days after distal middle …

Cerebral ischemic preconditioning protects against stroke, but is clinically feasible only when
the occurrence of stroke is predictable. Reperfusion plays a critical role in cerebral injury …

The functional and molecular similarities and distinctions between human and murine astrocytes
are poorly understood. Here, we report the development of an immunopanning method …

In recent years, the phosphoinositide-3-kinase/Akt cell survival signaling pathway has been
increasingly researched in the field of stroke. Akt activity is suggested to be upregulated by …

Stroke remains a leading cause of death and disability in the world. Over the past few decades
our understanding of the pathophysiology of stroke has increased, but greater insight is …

CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier (BBB) …

Object No definitive treatment exists to restore lost brain function following a stroke. Transplantation
of cultured neuronal cells has been shown to be safe and effective in animal models …