User profiles for J. C. Grotta

James C Grotta

Director Mobile Stroke Unit and Stroke Research, Memorial Hermann Hospital
Verified email at uth.tmc.edu
Cited by 124873

Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke: a statement for healthcare professionals from the …

…, OM Adeoye, AM Demchuk, JE Fugate, JC Grotta… - Stroke, 2016 - Am Heart Assoc
Purpose— To critically review and evaluate the science behind individual eligibility criteria (indication/inclusion
and contraindications/exclusion criteria) for intravenous recombinant …

[HTML][HTML] Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data

…, KS Butcher, SM Seyedsaadat, JC Grotta… - The Lancet …, 2018 - thelancet.com
Background Intracerebral haemorrhage growth is associated with poor clinical outcome and
is a therapeutic target for improving outcome. We aimed to determine the absolute risk and …

Acute stroke imaging research roadmap II

…, AM Demchuk, JB Fiebach, J Fiehler, JC Grotta… - Stroke, 2013 - Am Heart Assoc
Society of Neuroradiology, and the Foundation of the American Society of Neuroradiology
sponsored a series of working group meetings> 12 months, with the final meeting occurring …

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials

…, E Bluhmki, R Von Kummer, TG Brott, D Toni, JC Grotta… - The Lancet, 2010 - thelancet.com
Background Early administration of intravenous recombinant tissue plasminogen activator (rt-PA)
after ischaemic stroke improves outcome. Previous analysis of combined data from …

[HTML][HTML] Trial of endovascular thrombectomy for large ischemic strokes

…, MG Lansberg, MD Hill, JC Grotta… - … England Journal of …, 2023 - Mass Medical Soc
Background Trials of the efficacy and safety of endovascular thrombectomy in patients with
large ischemic strokes have been carried out in limited populations. Methods We performed a …

[HTML][HTML] Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke

AV Alexandrov, CA Molina, JC Grotta… - … England Journal of …, 2004 - Mass Medical Soc
Background Transcranial Doppler ultrasonography that is aimed at residual obstructive
intracranial blood flow may help expose thrombi to tissue plasminogen activator (t-PA). Our …

Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study

…, BC Tilley, M Lu, TG Brott, PC Lyden, JC Grotta… - Neurology, 2000 - AAN Enterprises
Background: The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA
Stroke Study showed a similar percentage of intracranial hemorrhage and good outcome in …

Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator

AV Alexandrov, JC Grotta - Neurology, 2002 - AAN Enterprises
Background: Arterial reocclusion has not been systematically studied despite the fact that 13%
of patients in the National Institute of Neurological Diseases and Stroke rt-PA Trial …

[PDF][PDF] Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease

…, RE Pyeritz, MN Singh, RL Dalman, JC Grotta… - The American Journal of …, 2009 - cell.com
The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major
component of the contractile apparatus in SMCs located throughout the arterial system. …

[HTML][HTML] Prospective, multicenter, controlled trial of mobile stroke units

JC Grotta, JM Yamal, SA Parker… - … England Journal of …, 2021 - Mass Medical Soc
Background Mobile stroke units (MSUs) are ambulances with staff and a computed tomographic
scanner that may enable faster treatment with tissue plasminogen activator (t-PA) than …