Although there have been numerous reports from around the world of mutations in the gene
of chromosome 7 known as CFTR (cystic fibrosis transmembrane conductance regulator), …

Background Several new targeted genes and clinical subtypes have been identified since
publication in 2008 of the report of the last international consensus meeting on diagnosis and …

Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid
precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive …

Objective We aimed to develop consensus-based recommendations for streamlining medical
communication among various health care professionals, to improve accuracy of diagnosis …

Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset
of patients. Here, we applied single-cell technologies to iCD lesions to address whether …

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …

Background Obesity and inflammation are highly integrated processes in the pathogenesis
of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular …

Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have
been shown to prevent the development of collagen-induced arthritis (CIA) in mice, …

Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide]
is a potent, selective antagonist of the human …

With explanatory covariates, the standard analysis for competing risks data involves modeling
the cause-specific hazard functions via a proportional hazards assumption. Unfortunately, …