The skeleton provides mechanical support for stature and locomotion, protects vital organs,
and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone …

Acute infective endocarditis is a complex disease with changing epidemiology and a rapidly
evolving knowledge base. To consistently achieve optimal outcomes in the management of …

Diarrhea from gastrointestinal infection remains a common problem. In industrialized countries,
management is aimed at reducing morbidity and defining groups that may benefit from …

Background: Multiple laboratory tests are used in the diagnosis and management of patients
with diabetes mellitus. The quality of the scientific evidence supporting the use of these …

Oxidative stress plays a critical role in the pathogenesis of atherosclerosis including the
formation of lipid laden macrophages and the development of inflammation. However, oxidative …

Abstract Space flight-induced bone loss has been attributed to a decrease in osteoblast
function, without a significant change in bone resorption. To determine the effect of microgravity (…

We measured free calcium and related variables before and after the subject changed from
the upright to the supine posture, doing 15 separate such experiments on 11 healthy men. …

Spaceflight, aging, and disuse lead to reduced BMD. This study shows that overexpression
of constitutively active RhoA restores actin cytoskeletal arrangement, enhances the …

Shear stress differentially regulates production of many vasoactive factors at the level of gene
expression in endothelial cells that may be mediated by mitogen-activated protein kinases, …

Background. . Herpes zoster occurs more commonly in patients taking immunosuppressive
medications, although the risk associated with different medications is poorly understood. …