Background. The prevalence of vesicoureteral reflux in normal children has been estimated
to be 0.4 % to 1.8 %. Based on epidemiological data, it can be estimated that 2.2 % of girls …

The cardiac extracellular matrix is a dynamic structural support network that is both influenced
by, and a regulator of, pathological remodeling and hypertrophic growth. In response to …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute
wound healing and long-term tissue remodeling with scarring. With myocardial infarction …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this day
1 , 2 , despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Muscular dystrophies comprise a diverse group of genetic disorders that lead to muscle
wasting and, in many instances, premature death 1 . Many mutations that cause muscular …

In the heart, augmented Ca 2+ fluxing drives contractility and ATP generation through
mitochondrial Ca 2+ loading. Pathologic mitochondrial Ca 2+ overload with ischemic injury …

10.7554/eLife.00772.001 A critical event in ischemia-based cell death is the opening of the
mitochondrial permeability transition pore (MPTP). However, the molecular identity of the …

… [1] MA Sargent and M. Darveniza, "The calculation of the double circuit outage rates of
transmission … MA Sargent and M. Darveniza: The authors are grateful for the discussion from Prof. …

The transcription factor GATA4 is a critical regulator of cardiac gene expression, modulating
cardiomyocyte differentiation and adaptive responses of the adult heart. We report what we …

Background: In the heart, acute injury induces a fibrotic healing response that generates
collagen-rich scarring that is at first protective but if inappropriately sustained can worsen heart …