We report a series of studies that assess the feasibility and sensitivity of imaging of herpes
virus type one thymidine kinase (HSV1-tk) gene transfer and expression with [ 124 I]-5-iodo-2…

OBJECTIVES: The aim of the study is to determine factors affecting ischaemic wound
healing and role of the angiosome concept in bypass surgery. DESIGN: Single-centre, …

Hepatocyte growth factor (HGF) is a potent angiogenic factor. The efficacy and safety of
intramuscular injection of a naked plasmid encoding human HGF gene (beperminogene …

OBJECTIVES:: The role of bypass to the distal arteries for patients with Buerger's disease (thromboangiitis
or TAO) remains controversial because of the high incidence of graft failure. …

Purpose: Endothelial cells (ECs) are subjected to the physical forces induced by blood flow.
The aim of this study was to directly compare the EC signaling pathway in response to cyclic …

We attempted to clarify the effect of different types of shear stress on endothelial cell (EC)
proliferation and survival. Bovine aortic ECs were subjected to either steady laminar, 1 Hz …

Background— Lymphedema is a disorder of the lymphatic vascular system characterized by
impaired lymphatic return and swelling of the extremities. Treatment for this disabling …

This phase III study assessed the efficacy and safety of sacubitril/valsartan compared with
those of olmesartan in Japanese patients with essential hypertension. Patients (n = 1161, …

… (16 or 52 weeks) was tested with one sample t-test; n, number of patients who continued …
Milligan, Makoto Nagasaki, and Takayoshi Sasajima are employees of Novartis Pharma KK …

The p38/mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAP kinase
2)/heat shock protein (HSP)25/27 pathway is thought to play a critical role in actin dynamics…