Pilocytic astrocytoma is the most common pediatric central nervous system glial neoplasm
and the most common pediatric cerebellar tumor. This tumor has a noteworthy benign …

Abstract The Hirntumorstudien (HIT)-LGG-1996 protocol offered a comprehensive treatment
strategy for pediatric patients with low-grade glioma (LGG), ie, observation, surgery …

Diencephalic syndrome is a rare but potentially lethal cause of failure to thrive in infants and
young children. The diencephalic syndrome includes clinical characteristics of severe …

Background The use of chemotherapy to manage newly diagnosed low grade glioma (LGG)
was first introduced in the 1980s. One randomised trial has studied two-versus four-drug …

Context Up to 20% of children with neurofibromatosis type 1 (NF1) develop low-grade optic
pathway gliomas (OPGs) that can result in endocrine dysfunction. Data on prevalence and …

Simple Summary Serious, poorly understood health issues affect young children with optic
pathway tumours. We studied the risk of developing life-limiting hormonal, metabolic, and …

Background In terms of overall survival (OS), limited data are available for the very long-term
outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy …

Context: Childhood craniopharyngiomas (CPs) are known to be associated with an
increased risk of excessive weight gain and hypothalamic obesity. Atypical clinical …

Objective The role of GH in early human growth is unclear. Congenital GH deficiency
(CGHD) provides a useful tool to explore this putative role. We have assessed the effects of …

Diencephalic gliomas may be grouped into 2 clinical categories. Optic pathway/
hypothalamus gliomas (OPG) arise primarily from a slower-growing juvenile pilocytic …