N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

JR Moffett, B Ross, P Arun, CN Madhavarao… - Progress in …, 2007 - Elsevier
The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Clinical proton MR spectroscopy in central nervous system disorders

G Öz, JR Alger, PB Barker, R Bartha, A Bizzi, C Boesch… - Radiology, 2014 - pubs.rsna.org
A large body of published work shows that proton (hydrogen 1 [1H]) magnetic resonance
(MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality …

Astrocyte biomarkers in Alzheimer's disease

SF Carter, K Herholz, P Rosa-Neto, L Pellerin… - Trends in molecular …, 2019 - cell.com
Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely
overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an …

In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T

I Tkáč, G Öz, G Adriany, K Uğurbil… - Magnetic Resonance in …, 2009 - Wiley Online Library
A comprehensive comparative study of metabolite quantification from the human brain was
performed on the same 10 subjects at 4T and 7T using MR scanners with identical consoles …

MR spectroscopic imaging: principles and recent advances

S Posse, R Otazo, SR Dager… - Journal of Magnetic …, 2013 - Wiley Online Library
MR spectroscopic imaging (MRSI) has become a valuable tool for quantifying metabolic
abnormalities in human brain, prostate, breast and other organs. It is used in routine clinical …

Imaging artifacts at 3.0 T

MA Bernstein, J Huston III… - Journal of Magnetic …, 2006 - Wiley Online Library
Clinical MRI at a field strength of 3.0 T is finding increasing use. However, along with the
advantages of 3.0 T, such as increased SNR, there can be drawbacks, including increased …

A review of MR physics: 3T versus 1.5 T

BJ Soher, BM Dale, EM Merkle - Magnetic resonance imaging clinics of …, 2007 - Elsevier
This article illustrates changes in the underlying physics concepts related to increasing the
main magnetic field from 1.5 T to 3T. The effects of these changes on tissue constants and …

The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders

A Prajapati, S Mehan, Z Khan - Biogerontology, 2023 - Springer
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …

[HTML][HTML] Molecular and imaging biomarkers in Alzheimer's disease: a focus on recent insights

C Villa, M Lavitrano, E Salvatore, R Combi - Journal of Personalized …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease among the
elderly, affecting millions of people worldwide and clinically characterized by a progressive …

Reduced hippocampal glutamate in Alzheimer disease

R Rupsingh, M Borrie, M Smith, JL Wells, R Bartha - Neurobiology of aging, 2011 - Elsevier
Altered neurometabolic profiles have been detected in Alzheimer disease (AD) using 1H
magnetic resonance spectroscopy (MRS), but no definitive biomarker of mild cognitive …