Huntington disease: natural history, biomarkers and prospects for therapeutics

CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Structural MRI in Huntington's disease and recommendations for its potential use in clinical trials

N Georgiou-Karistianis, R Scahill, SJ Tabrizi… - Neuroscience & …, 2013 - Elsevier
Huntington's disease (HD) results in progressive impairment of motor and cognitive function
and neuropsychiatric disturbance. There are no disease-modifying treatments available, but …

Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice

YP Deng, T Wong, C Bricker-Anthony, B Deng… - Neurobiology of …, 2013 - Elsevier
Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …

[HTML][HTML] Linking white matter and deep gray matter alterations in premanifest Huntington disease

AV Faria, JT Ratnanather, DJ Tward, DS Lee… - Neuroimage …, 2016 - Elsevier
Huntington disease (HD) is a fatal progressive neurodegenerative disorder for which only
symptomatic treatment is available. A better understanding of the pathology, and …

[HTML][HTML] Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis

N De Stefano, ML Stromillo, F Rossi, M Battaglini… - PloS one, 2011 - journals.plos.org
Objective To improve the characterization of asymptomatic subjects with brain magnetic
resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a …

Movement disorders: role of imaging in diagnosis

M Mascalchi, A Vella, R Ceravolo - Journal of magnetic …, 2012 - Wiley Online Library
Magnetic resonance imaging (MRI and single‐photon emission computed tomography
(SPECT) have a considerable role in the diagnosis of the single patient with movement …

Magnetic resonance imaging striatal volumes: A biomarker for clinical trials in Huntington's disease

EH Aylward - Movement Disorders, 2014 - Wiley Online Library
An abundance of research shows that magnetic resonance imaging (MRI) striatal volumes
decrease long before diagnosis of Huntington's disease (HD) and closely track disease …

The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease

JB Pérot, E Brouillet, J Flament - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Huntington's disease is an inherited disorder characterized by psychiatric, cognitive, and
motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal …

Structural imaging in premanifest and manifest Huntington disease

RI Scahill, R Andre, SJ Tabrizi, EH Aylward - Handbook of clinical …, 2017 - Elsevier
Huntington disease (HD) neuropathology has a devastating effect on brain structure and
consequently brain function; neuroimaging provides a means to assess these effects in …

Structural magnetic resonance imaging in Huntington's disease

H Wilson, G Dervenoulas, M Politis - International review of neurobiology, 2018 - Elsevier
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused
by expansion of the CAG repeat in the huntingtin gene. HD is characterized clinically by …