Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
Structural MRI in Huntington's disease and recommendations for its potential use in clinical trials
N Georgiou-Karistianis, R Scahill, SJ Tabrizi… - Neuroscience & …, 2013 - Elsevier
Huntington's disease (HD) results in progressive impairment of motor and cognitive function
and neuropsychiatric disturbance. There are no disease-modifying treatments available, but …
and neuropsychiatric disturbance. There are no disease-modifying treatments available, but …
Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice
YP Deng, T Wong, C Bricker-Anthony, B Deng… - Neurobiology of …, 2013 - Elsevier
Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
[HTML][HTML] Linking white matter and deep gray matter alterations in premanifest Huntington disease
Huntington disease (HD) is a fatal progressive neurodegenerative disorder for which only
symptomatic treatment is available. A better understanding of the pathology, and …
symptomatic treatment is available. A better understanding of the pathology, and …
[HTML][HTML] Improving the characterization of radiologically isolated syndrome suggestive of multiple sclerosis
Objective To improve the characterization of asymptomatic subjects with brain magnetic
resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a …
resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a …
Movement disorders: role of imaging in diagnosis
M Mascalchi, A Vella, R Ceravolo - Journal of magnetic …, 2012 - Wiley Online Library
Magnetic resonance imaging (MRI and single‐photon emission computed tomography
(SPECT) have a considerable role in the diagnosis of the single patient with movement …
(SPECT) have a considerable role in the diagnosis of the single patient with movement …
Magnetic resonance imaging striatal volumes: A biomarker for clinical trials in Huntington's disease
EH Aylward - Movement Disorders, 2014 - Wiley Online Library
An abundance of research shows that magnetic resonance imaging (MRI) striatal volumes
decrease long before diagnosis of Huntington's disease (HD) and closely track disease …
decrease long before diagnosis of Huntington's disease (HD) and closely track disease …
The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease
JB Pérot, E Brouillet, J Flament - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Huntington's disease is an inherited disorder characterized by psychiatric, cognitive, and
motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal …
motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal …
Structural imaging in premanifest and manifest Huntington disease
RI Scahill, R Andre, SJ Tabrizi, EH Aylward - Handbook of clinical …, 2017 - Elsevier
Huntington disease (HD) neuropathology has a devastating effect on brain structure and
consequently brain function; neuroimaging provides a means to assess these effects in …
consequently brain function; neuroimaging provides a means to assess these effects in …
Structural magnetic resonance imaging in Huntington's disease
H Wilson, G Dervenoulas, M Politis - International review of neurobiology, 2018 - Elsevier
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused
by expansion of the CAG repeat in the huntingtin gene. HD is characterized clinically by …
by expansion of the CAG repeat in the huntingtin gene. HD is characterized clinically by …