Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …

Pain of the orofacial region is the primary complaint for which patients seek treatment. Of all
the orofacial pain conditions, one condition that possess a significant global health problem …

Fibromyalgia is a complex and heterogeneous clinical syndrome, mainly characterized by
the presence of widespread pain, possibly associated with a variety of other symptoms …

Central sensitivity syndromes are characterized by distressing symptoms, such as pain and
fatigue, in the absence of clinically obvious pathology. The scientific underpinnings of these …

Recent translational work has shown that fibromyalgia might be an autoimmune condition
with pathogenic mechanisms mediated by a peripheral, pain-inducing action of …

Chronic neuropathic pain after a spinal cord injury (SCI) continues to be a complex condition
that is difficult to manage due to multiple underlying pathophysiological mechanisms and the …

Background Increased cortical excitability has been hypothesized to play a critical role in
various neurological disorders, such as restless legs syndrome, epilepsy and migraine …

Brain neuroimaging has been widely used to investigate the bran signature of chronic
orofacial pain, including trigeminal neuropathic pain (TNP) and pain related to …

Research suggests that fibromyalgia is a central, widespread pain syndrome supported by a
generalized disturbance in central nervous system pain processing. Over the past decades …