Developmental venous anomalies (DVAs), previously called venous angiomas, are the most
frequently encountered cerebral vascular malformations. However, DVA is considered to be …

Developmental venous anomalies (DVAs) are the most common slow-flow venous
malformation in the brain. Most DVAs are benign. Uncommonly, DVAs can become …

Cavernous malformations (CMs) are uncommon lesions occurring in the central nervous
system, with an incidence of approximately 0.5% in the general population and constituting …

Background and purpose To test the hypothesis that the prevalence of cerebral cavernous
malformation (CCM) associated with developmental venous anomalies (DVAs) increases …

Goal: Sporadic brain cavernous malformations commonly correlate with developmental
venous anomalies; however, developmental venous anomalies may exist without cavernous …

The etiology of multiple sclerosis (MS) is currently understood to be autoimmune. However,
there is a long history and growing evidence for disrupted vasculature and flow within the …

Somatic gain-of-function (GOF) mutations in phosphatidylinositol-4, 5-bisphosphate 3-
kinase catalytic subunit alpha (PIK3CA), the catalytic subunit of phosphoinositide 3-kinase …

Objective Despite the low annual risk of hemorrhage associated with a cavernous
malformation (CM)(0.6%–1.1% per year), the risk of rehemorrhage rate and severity of …

BACKGROUND AND PURPOSE: Abnormal signal in the drainage territory of developmental
venous anomalies has been well described in adults but has been incompletely investigated …

Background: Cerebral cavernous malformations (CCMs) are a major type of cerebrovascular
lesions of proven genetic origin that occur in either sporadic (sCCM) or familial (fCCM) …