[HTML][HTML] A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma

J Bolcaen, J Kleynhans, S Nair, J Verhoeven… - Theranostics, 2021 - ncbi.nlm.nih.gov
Despite numerous clinical trials and pre-clinical developments, the treatment of glioblastoma
(GB) remains a challenge. The current survival rate of GB averages one year, even with an …

[HTML][HTML] Radionuclide generators: The prospect of availing PET radiotracers to meet current clinical needs and future research demands

A Dash, R Chakravarty - American journal of nuclear medicine and …, 2019 - ncbi.nlm.nih.gov
Targeted molecular imaging with positron emission tomography (PET) constitutes a
successful technique for detecting and diagnosing disease conditions promptly and …

Performance of 18F-FDG, 11C-methionine, and 18F-FET PET for glioma grading: a meta-analysis

AH Katsanos, GA Alexiou, AD Fotopoulos… - Clinical nuclear …, 2019 - journals.lww.com
Purpose Gliomas constitute the most frequent primary brain tumors. Glioblastoma, the most
common and malignant glioma in adults, has dismal prognosis with any current therapy. On …

[HTML][HTML] Feasibility on the use of radiomics features of 11 [C]-MET PET/CT in central nervous system tumours: Preliminary results on potential grading discrimination …

G Russo, A Stefano, P Alongi, A Comelli, B Catalfamo… - Current …, 2021 - mdpi.com
Background/Aim: Nowadays, Machine Learning (ML) algorithms have demonstrated
remarkable progress in image-recognition tasks and could be useful for the new concept of …

Copper radiopharmaceuticals for theranostic applications

A Ahmedova, B Todorov, N Burdzhiev… - European Journal of …, 2018 - Elsevier
The growing advancement in nuclear medicine challenges researchers from several
different fields to integrate imaging and therapeutic modalities in a theranostic …

PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors

K Tateishi, T Nakamura, TA Juratli, EA Williams… - Clinical Cancer …, 2019 - AACR
Purpose: Oligodendroglioma has a relatively favorable prognosis, however, often
undergoes malignant progression. We hypothesized that preclinical models of …

[HTML][HTML] BRAF V600E mutation mediates FDG-methionine uptake mismatch in polymorphous low-grade neuroepithelial tumor of the young

K Tateishi, N Ikegaya, N Udaka, J Sasame… - Acta Neuropathologica …, 2020 - Springer
We present a case of a 14-year old boy with tumor-associated refractory epilepsy. Positron
emission tomography imaging demonstrated a region with heterogeneous high 11 C …

Discrimination between primary low-grade and high-grade glioma with 11C-methionine PET: a bivariate diagnostic test accuracy meta-analysis

A Falk Delgado, A Falk Delgado - The British journal of …, 2018 - academic.oup.com
Objective: To perform a meta-analysis evaluating the diagnostic accuracy of 11C-methionine
(MET) positron emission tomography (PET) to discriminate between primary low-grade …

Repurposing drugs as pro‐oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

SJ Ralph, S Nozuhur, RA ALHulais… - Medicinal Research …, 2019 - Wiley Online Library
Over the last decade, three major advances have contributed in improving the response
rates against cancer including, immunotherapy; greater understanding of the molecular …

[HTML][HTML] 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study

EA Pérès, J Toutain, LP Paty, D Divoux, M Ibazizène… - EJNMMI research, 2019 - Springer
Abstract Background Diacetyl-bis (N4-methylthiosemicarbazone), labeled with 64Cu (64 Cu-
ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various …