Importance Imaging biomarkers in Parkinson disease (PD) are increasingly important for
monitoring progression in clinical trials and also have the potential to improve clinical care …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

Background Absence of a hyperintense, ovoid area within the dorsolateral border of the
otherwise hypointense pars compacta of the substantia nigra (referred to as dorsolateral …

Historically, magnetic resonance imaging (MRI) has contributed little to the study of
Parkinson's disease (PD), but modern MRI approaches have unveiled several …

Introduction There is currently no definitive diagnostic test for Parkinson's disease (PD) and
the current diagnostic procedure primarily relies on clinical manifestations. A hypointense …

In this review, we describe how different neuroimaging tools have been used to identify
novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the …

Background and purpose Differential diagnosis between Parkinson's disease (PD) and
Atypical Parkinsonisms, mainly Progressive Supranuclear Palsy (PSP) and Multiple System …

The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …

Iron is essential for cellular development and maintenance of multiple physiological
processes in the central nervous system. The disturbance of its homeostasis leads to …

Purpose We investigated whether diffusion kurtosis imaging (DKI) and quantitative
susceptibility mapping (QSM) could detect pathological changes that occur in Parkinson's …