Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments

SL Perrin, MS Samuel, B Koszyca… - Biochemical Society …, 2019 - portlandpress.com
Glioblastoma is the deadliest form of brain cancer. Aside from inadequate treatment options,
one of the main reasons glioblastoma is so lethal is the rapid growth of tumour cells coupled …

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

P Chen, W Wang, R Liu, J Lyu, L Zhang, B Li, B Qiu… - Nature, 2022 - nature.com
Animals constantly receive various sensory stimuli, such as odours, sounds, light and touch,
from the surrounding environment. These sensory inputs are essential for animals to search …

[HTML][HTML] Survival of glioblastoma in relation to tumor location: a statistical tumor atlas of a population-based cohort

EH Fyllingen, LE Bø, I Reinertsen, AS Jakola… - Acta …, 2021 - Springer
Purpose Previous studies on the effect of tumor location on overall survival in glioblastoma
have found conflicting results. Based on statistical maps, we sought to explore the effect of …

[HTML][HTML] Radiogenomic Predictors of Recurrence in Glioblastoma—A Systematic Review

F Corr, D Grimm, B Sass, M Pojskić, JW Bartsch… - Journal of Personalized …, 2022 - mdpi.com
Glioblastoma, as the most aggressive brain tumor, is associated with a poor prognosis and
outcome. To optimize prognosis and clinical therapy decisions, there is an urgent need to …

[HTML][HTML] Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) …

J Wen, W Chen, Y Zhu, P Zhang - BMC cancer, 2021 - Springer
Background Glioblastoma (GBM) is a highly malignant brain tumor with poor survival and
prognosis. Randomized trials have demonstrated that chemotherapy improves survival in …

[HTML][HTML] Accurate MR image registration to anatomical reference space for diffuse glioma

M Visser, J Petr, DMJ Müller, RS Eijgelaar… - Frontiers in …, 2020 - frontiersin.org
To summarize the distribution of glioma location within a patient population, registration of
individual MR images to anatomical reference space is required. In this study, we quantified …

Magnetic resonance perfusion image features uncover an angiogenic subgroup of glioblastoma patients with poor survival and better response to antiangiogenic …

TT Liu, AS Achrol, LA Mitchell, SA Rodriguez… - Neuro …, 2017 - academic.oup.com
Background. In previous clinical trials, antiangiogenic therapies such as bevacizumab did
not show efficacy in patients with newly diagnosed glioblastoma (GBM). This may be a result …

[HTML][HTML] Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods

A de Sitter, M Visser, I Brouwer, KS Cover… - European …, 2020 - Springer
Background Recent studies have created awareness that facial features can be
reconstructed from high-resolution MRI. Therefore, data sharing in neuroimaging requires …

[HTML][HTML] Mass effect deformation heterogeneity (MEDH) on gadolinium-contrast T1-weighted MRI is associated with decreased survival in patients with right cerebral …

P Prasanna, J Mitra, N Beig, A Nayate, J Patel… - Scientific reports, 2019 - nature.com
Subtle tissue deformations caused by mass-effect in Glioblastoma (GBM) are often not
visually evident, and may cause neurological deficits, impacting survival. Radiomic features …

White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma

A Salvalaggio, L Pini, M Gaiola, A Velco… - JAMA …, 2023 - jamanetwork.com
Importance The prognosis of overall survival (OS) in patients with glioblastoma (GBM) may
depend on the underlying structural connectivity of the brain. Objective To examine the …