The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

Spinal cord involvement is an important cause of disability in patients with multiple sclerosis
or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can …

Objective To assess whether cervical spinal cord atrophy heralds the onset of progressive
MS. Methods We studied 34 individuals with radiologically isolated syndrome (RIS) and 31 …

Background As disease progression remains poorly understood in multiple sclerosis (MS),
we aim to investigate the sequence in which different disease milestones occur using a …

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but
longitudinal assessments on magnetic resonance imaging using segmentation‐based …

Objective To characterize the distribution and regional evolution of cervical cord atrophy in
patients with multiple sclerosis (MS) in a multicenter dataset. Methods MRI and clinical …

There is an increasing need of sharing harmonized data from large, cooperative studies as
this is essential to develop new diagnostic and prognostic biomarkers. In the field of multiple …

Background and purpose Both optical coherence tomography (OCT) and magnetic
resonance imaging (MRI) volumetric measures have been postulated as potential …

As atrophy represents the most relevant driver of progression in multiple sclerosis (MS), we
investigated the impact of different patterns of brain and spinal cord atrophy on disability …

Background: Body fluid and structural imaging biomarkers give information on
neurodegeneration. The relationship over time is not known in multiple sclerosis. Objective …