Malformations of cortical development are a group of rare disorders commonly manifesting
with developmental delay, cerebral palsy or seizures. The neurological outcome is …

Monogenic cerebral vasculopathy is a rare but progressively recognizable cause of pediatric
cerebral vasculopathy manifesting as early as fetal life. These monogenic cerebral …

Objective To establish progression of imaging biomarkers of stroke, arterial steno-occlusive
disease, and white matter injury in patients with smooth muscle dysfunction syndrome …

Objectives Mutations in the MYH11 gene result in smooth muscle cell dysfunction and are
associated with familial thoracic aortic aneurysms and dissection. We describe a pediatric …

Although less common than in adults, stroke is the sixth leading cause of death in children,
affecting~ 2–13 children per 100,000 under 18 years of age. Because it is underappreciated …

Pediatric stroke encompasses different causes, clinical presentations, and associated
conditions across ages. Although it is relatively uncommon, pediatric stroke presents with …

Nuclear receptor-related 1 (Nurr1) protein has been identified as an obligatory transcription
factor in midbrain dopaminergic neurogenesis, but the global set of human NURR1 target …

Cerebral vasculitis is increasingly recognized as a common cause of pediatric arterial
stroke. It can present with focal neurological deficits, psychiatric manifestations, seizures …

BACKGROUND AND PURPOSE: Pathogenic variants in the ACTA2 gene cause a
distinctive arterial phenotype that has recently been described to be associated with brain …

Background Cerebral vasculopathies frequently lead to severe medical conditions such as
stroke or intracranial hemorrhage and have a broad range of possible etiologies that require …