High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis

H Meng, VM Tutino, J Xiang… - American Journal of …, 2014 - Am Soc Neuroradiology
Increasing detection of unruptured intracranial aneurysms, catastrophic outcomes from
subarachnoid hemorrhage, and risks and cost of treatment necessitate defining objective …

What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review

KM Saqr, S Rashad, S Tupin… - Journal of Cerebral …, 2020 - journals.sagepub.com
Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic
using computational fluid dynamics (CFD), limited progress has been made towards …

Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American Heart Association …

BG Thompson, RD Brown Jr, S Amin-Hanjani… - Stroke, 2015 - Am Heart Assoc
Purpose—The aim of this updated statement is to provide comprehensive and evidence-
based recommendations for management of patients with unruptured intracranial …

Hemodynamic–morphologic discriminants for intracranial aneurysm rupture

J Xiang, SK Natarajan, M Tremmel, D Ma, J Mocco… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—The purpose of this study was to identify significant
morphological and hemodynamic parameters that discriminate intracranial aneurysm …

CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment

J Xiang, VM Tutino, KV Snyder… - American Journal of …, 2014 - Am Soc Neuroradiology
Image-based computational fluid dynamics holds a prominent position in the evaluation of
intracranial aneurysms, especially as a promising tool to stratify rupture risk. Current …

Hemodynamic differences between unruptured and ruptured intracranial aneurysms during observation

H Takao, Y Murayama, S Otsuka, Y Qian, A Mohamed… - Stroke, 2012 - Am Heart Assoc
Background and Purpose—We evaluated several hemodynamic parameters for the
prediction of rupture in a data set of initially unruptured aneurysms, including aneurysms that …

[HTML][HTML] Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms

VL Rayz, L Boussel, L Ge, JR Leach, AJ Martin… - Annals of biomedical …, 2010 - Springer
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth,
can present additional risk of thrombo-embolism. The role of hemodynamics in the …

Association of hemodynamic factors with intracranial aneurysm formation and rupture: systematic review and meta-analysis

A Can, R Du - Neurosurgery, 2016 - journals.lww.com
BACKGROUND: Recent evidence suggests a link between the magnitude and distribution of
hemodynamic factors and the formation and rupture of intracranial aneurysms. However …

Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture–a systematic review and novel parameter-ranking tool

L Liang, DA Steinman, O Brina, C Chnafa… - Journal of …, 2019 - jnis.bmj.com
Background Intracranial aneurysms (IAs) are vascular dilations on cerebral vessels that
affect between 1%–5% of the general population, and can cause life-threatening intracranial …

Shear stress and aneurysms: a review

B Staarmann, M Smith, CJ Prestigiacomo - Neurosurgical focus, 2019 - thejns.org
Wall shear stress, the frictional force of blood flow tangential to an artery lumen, has been
demonstrated in multiple studies to influence aneurysm formation and risk of rupture. In this …