Age, APOE and sex: triad of risk of Alzheimer's disease
Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …
Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit
It is widely assumed that incipient protein pathology in the medial temporal lobe instigates
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …
the loss of episodic memory in Alzheimer's disease, one of the earliest cognitive deficits in …
Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy
Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …
The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2
Ongoing efforts to improve survival, and enhance quality of life have led biomedical
research to focus on disease and the mechanisms that increase risk for disease. The other …
research to focus on disease and the mechanisms that increase risk for disease. The other …
[HTML][HTML] Apolipoprotein E genotype e2: neuroprotection and its limits
H Kim, DP Devanand, S Carlson… - Frontiers in Aging …, 2022 - frontiersin.org
In this review, we comprehensively, qualitatively, and critically synthesized several features
of APOE-e2, a known APOE protective variant, including its associations with longevity …
of APOE-e2, a known APOE protective variant, including its associations with longevity …
Gray matter maturation and cognition in children with different APOE ε genotypes
Objective: The aims of the current study were to determine whether children with the 6
different APOE ε genotypes show differences in gray matter maturation, particularly for those …
different APOE ε genotypes show differences in gray matter maturation, particularly for those …
[HTML][HTML] Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging
Mounting evidence indicates that myelin breakdown may represent an early phenomenon in
neurodegeneration, including Alzheimer's disease (AD). Understanding the factors …
neurodegeneration, including Alzheimer's disease (AD). Understanding the factors …
White matter abnormalities associated with Alzheimer's disease and mild cognitive impairment: a critical review of MRI studies
M Radanovic, FRS Pereira, F Stella… - Expert review of …, 2013 - Taylor & Francis
In this article, the authors aim to present a critical review of recent MRI studies addressing
white matter (WM) abnormalities in Alzheimer's disease (AD) and mild cognitive impairment …
white matter (WM) abnormalities in Alzheimer's disease (AD) and mild cognitive impairment …
Relationship between APOE genotype and structural MRI measures throughout adulthood in the study of health in Pomerania population-based cohort
BACKGROUND AND PURPOSE: The presence of the apolipoprotein E ε 4 allele is the
strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that …
strongest sporadic Alzheimer disease genetic risk factor. We hypothesized that …
[HTML][HTML] Longitudinal white matter and cognitive development in pediatric carriers of the apolipoprotein ε4 allele
We have previously demonstrated cross-sectional differences in magnetic resonance
imaging (MRI) measurements of white matter myelin and gray matter in infants with or …
imaging (MRI) measurements of white matter myelin and gray matter in infants with or …