White matter hyperintensities, cognitive impairment and dementia: an update
ND Prins, P Scheltens - Nature Reviews Neurology, 2015 - nature.com
White matter hyperintensities (WMHs) in the brain are the consequence of cerebral small
vessel disease, and can easily be detected on MRI. Over the past three decades, research …
vessel disease, and can easily be detected on MRI. Over the past three decades, research …
Structural imaging measures of brain aging
SN Lockhart, C DeCarli - Neuropsychology review, 2014 - Springer
During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …
with changes in cognitive ability. This review presents data from neuroimaging studies of …
Changes in normal-appearing white matter precede development of white matter lesions
M De Groot, BFJ Verhaaren, R De Boer, S Klein… - Stroke, 2013 - Am Heart Assoc
Background and Purpose—It is unknown whether white matter lesions (WML) develop
abruptly in previously normal brain areas, or whether tissue changes are already present …
abruptly in previously normal brain areas, or whether tissue changes are already present …
MRI measurements of blood-brain barrier function in dementia: a review of recent studies
R Raja, GA Rosenberg, A Caprihan - Neuropharmacology, 2018 - Elsevier
Blood-brain barrier (BBB) separates the systemic circulation and the brain, regulating
transport of most molecules to protect the brain microenvironment. Multiple structural and …
transport of most molecules to protect the brain microenvironment. Multiple structural and …
Bayesian model selection for pathological neuroimaging data applied to white matter lesion segmentation
CH Sudre, MJ Cardoso, WH Bouvy… - IEEE transactions on …, 2015 - ieeexplore.ieee.org
In neuroimaging studies, pathologies can present themselves as abnormal intensity
patterns. Thus, solutions for detecting abnormal intensities are currently under investigation …
patterns. Thus, solutions for detecting abnormal intensities are currently under investigation …
[HTML][HTML] Improving alignment in tract-based spatial statistics: evaluation and optimization of image registration
Anatomical alignment in neuroimaging studies is of such importance that considerable effort
is put into improving the registration used to establish spatial correspondence. Tract-based …
is put into improving the registration used to establish spatial correspondence. Tract-based …
White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain
Background and Purpose—Aging is accompanied by clinically silent cerebral white matter
injury identified through white matter hyperintensities (WMHs) on fluid-attenuated inversion …
injury identified through white matter hyperintensities (WMHs) on fluid-attenuated inversion …
Development of white matter hyperintensity is preceded by reduced cerebrovascular reactivity
Objective White matter hyperintensities (WMH) observed on neuroimaging of elderly
individuals are associated with cognitive decline and disability. However, the pathogenesis …
individuals are associated with cognitive decline and disability. However, the pathogenesis …
[HTML][HTML] Fibrosis: a key feature of Fabry disease with potential therapeutic implications
F Weidemann, MD Sanchez-Niño, J Politei… - Orphanet journal of rare …, 2013 - Springer
Fabry disease is a rare X-linked hereditary disease caused by mutations in the AGAL gene
encoding the lysosomal enzyme alpha-galactosidase A. Enzyme replacement therapy (ERT) …
encoding the lysosomal enzyme alpha-galactosidase A. Enzyme replacement therapy (ERT) …
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
Background and Objectives White matter hyperintensities (WMHs) are frequent imaging
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …
features of small vessel disease (SVD) and related to poor clinical outcomes. WMH …