Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Radiotherapy with high-energy charged particles has become an attractive therapeutic
option for patients with several tumour types because this approach better spares healthy …

Background and purpose A constant relative biological effectiveness (RBE) is used for
clinical proton therapy; however, experimental evidence indicates that RBE can vary. We …

Purpose Proton therapy can allow for superior avoidance of normal tissues. A widespread
consensus has been reached that proton therapy should be used for patients with curable …

Purpose To investigate if radiographic imaging changes defined as necrosis correlate with
regions in the brain with elevated linear energy transfer (LET) for proton radiation therapy …

Purpose The clinical significance of magnetic resonance imaging (MRI) changes after
radiation therapy (RT) in children with ependymoma is not well defined. We compared …

The purpose of this study was to investigate the feasibility of incorporating linear energy
transfer (LET) into the optimization of intensity modulated proton therapy (IMPT) plans …

BACKGROUND AND PURPOSE: Proton radiotherapy has been increasingly utilized to treat
pediatric brain tumors, however, limited information exists regarding radiation necrosis …

Purpose Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a rare
cancer primarily affecting children younger than 5 years old. Because patients are young …

BACKGROUND AND PURPOSE: The intracranial volume is commonly used for correcting
regional brain volume measurements for variations in head size. Accurate intracranial …