Cognitive dysfunction is increasingly recognized as an important comorbidity of diabetes
mellitus. Different stages of diabetes-associated cognitive dysfunction exist, each with …

Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Background Perivascular spaces, visible on brain magnetic resonance imaging, are thought
to be associated with small vessel disease, neuroinflammation, and to be important for …

In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

Enlarged perivascular spaces (PVS) are structural brain changes visible in MRI, are
common in aging, and are considered a reflection of cerebral small vessel disease. As such …

Background and Purpose: The causes of recurrent ischemic stroke despite anticoagulation
for atrial fibrillation are uncertain but might include small vessel occlusion. We investigated …

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is
thought to play a role in the pathogenesis of cognitive disorders. Identifying the etiologies of …

Objective To cross-sectionally relate multiple small vessel disease (SVD) neuroimaging
markers to cognition among older adults. Methods Vanderbilt Memory & Aging Project …

Perivascular spaces (PVS) and their enlargement (EPVS) have been gaining interest as
EPVS can be visualized non-invasively by magnetic resonance imaging (MRI) when viewing …