Sickle cell disease (SCD) is the most common inherited single-gene disease. Complications
include chronic anaemia, reduced oxygen-carrying capability, and cerebral vasculopathy …

Introduction: Over the past decades, neuroimaging studies have clarified that a significant
proportion of patients with sickle cell disease (SCD) have functionally significant brain …

Objective To determine mechanisms underlying regional vulnerability to infarction in sickle
cell disease (SCD) by measuring voxel-wise cerebral blood flow (CBF), oxygen extraction …

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell
anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress …

It is well-established that patients with sickle cell disease (SCD) are at substantial risk of
neurological complications, including overt and silent stroke, microstructural injury, and …

Background Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell
disease beyond the baseline elevated stroke risk in this vulnerable population. The …

Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic
systemic and cerebral vascular disease that leads to early and cumulative neurological …

Sickle cell disease (SCD) is a chronic blood disorder that is often associated with acute and
chronic cerebrovascular complications, including strokes and impaired cognition. Using …

Sickle cell disease is the most common hereditary hemoglobinopathy, which results in
abnormally shaped and rigid red blood cells. These sickle‐shaped red blood cells cause …

Objective Children with sickle cell disease (SCD) experience cognitive deficits even when
unaffected by stroke. Using functional connectivity magnetic resonance imaging (MRI) as a …