[PDF][PDF] Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

BR Stockwell, JPF Angeli, H Bayir, AI Bush, M Conrad… - Cell, 2017 - cell.com
Ferroptosis is a form of regulated cell death characterized by the iron-dependent
accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that …

[HTML][HTML] Glutathione in the Brain

K Aoyama - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

[PDF][PDF] Breakdown of an ironclad defense system: the critical role of NRF2 in mediating ferroptosis

A Anandhan, M Dodson, CJ Schmidlin, P Liu… - Cell chemical …, 2020 - cell.com
Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation
dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated …

[HTML][HTML] Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

S Kim, SW Kang, J Joo, SH Han, H Shin, BY Nam… - Cell Death & …, 2021 - nature.com
Kidney tubular cell death induced by transforming growth factor-β1 (TGF-β1) is known to
contribute to diabetic nephropathy, a major complication of diabetes. Caspase-3-dependent …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

[HTML][HTML] Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

AA Belaidi, S Masaldan, A Southon, P Kalinowski… - Molecular …, 2022 - nature.com
Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's
disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is …

Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance

S Ayton, S Portbury, P Kalinowski… - Alzheimer's & …, 2021 - Wiley Online Library
Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

[HTML][HTML] Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

H Nishizawa, M Matsumoto, T Shindo… - Journal of Biological …, 2020 - ASBMB
Ferroptosis is an iron-dependent programmed cell death event, whose regulation and
physiological significance remain to be elucidated. Analyzing transcriptional responses of …

[HTML][HTML] Ferroptosis, a potential therapeutic target in Alzheimer's disease

K Chen, X Jiang, M Wu, X Cao, W Bao… - Frontiers in Cell and …, 2021 - frontiersin.org
Cell death is a common phenomenon in the progression of Alzheimer's disease (AD).
However, the mechanism of triggering the death of neuronal cells remains unclear …

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

PJ Derry, ML Hegde, GR Jackson, R Kayed… - Progress in …, 2020 - Elsevier
The complexity of Alzheimer's disease (AD) complicates the search for effective treatments.
While the key roles of pathologically modified proteins has occupied a central role in …