BACKGROUND AND PURPOSE: GM is typically affected in HD since the presymptomatic
stage. Our aim was to investigate with MT MR imaging the microstructural changes of the …

BACKGROUND AND PURPOSE: MTI has the potential to detect abnormalities in normal-
appearing white and gray matter on conventional MR imaging. Early detection methods and …

BACKGROUND AND PURPOSE: MTI is a quantitative MR imaging technique that has
recently demonstrated structural integrity differences between controls and patients with HD …

PURPOSE: To investigate whether diffusion-weighted and magnetization transfer (MT)
magnetic resonance (MR) imaging depict regional and/or global brain abnormalities in …

To investigate whether magnetization transfer imaging (MTI) is a useful detector of diffuse
brain abnormalities in 'premanifest'carriers of the Huntington's disease (HD) gene mutation …

Objective: To concurrently investigate with magnetic resonance (MR) the brain activation
and regional brain atrophy in patients with Huntington disease (HD). Methods: Nine …

Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage
disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to …

White matter (WM) degeneration is an important feature of Huntington's disease (HD)
neuropathology. To investigate WM degeneration we used Diffusion Tensor Imaging and …

Huntington's disease is an inherited neurodegenerative condition characterized by motor
dysfunction, cognitive impairment and neuropsychiatric disturbance. The effects of the …

Huntington's disease (HD) leads to white matter (WM) degeneration that may be due to an
early breakdown in axon myelination but in vivo imaging correlates of demyelination remain …