Analysis of white matter damage in patients with multiple sclerosis via a novel in vivo MR method for measuring myelin, axons, and g-ratio
A Hagiwara, M Hori, K Yokoyama… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Myelin and axon volume fractions can now be estimated
via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer …
via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer …
White matter abnormalities in multiple sclerosis evaluated by quantitative synthetic MRI, diffusion tensor imaging, and neurite orientation dispersion and density …
BACKGROUND AND PURPOSE: A number of MR-derived quantitative metrics have been
suggested to assess the pathophysiology of MS, but the reports about combined analyses of …
suggested to assess the pathophysiology of MS, but the reports about combined analyses of …
Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging
Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple
sclerosis; however, a detailed characterization of the interaction between myelin and axon …
sclerosis; however, a detailed characterization of the interaction between myelin and axon …
Imaging G-ratio in multiple sclerosis using high-gradient diffusion MRI and macromolecular tissue volume
BACKGROUND AND PURPOSE: Remyelination represents an area of great therapeutic
interest in multiple sclerosis but currently lacks a robust imaging marker. The purpose of this …
interest in multiple sclerosis but currently lacks a robust imaging marker. The purpose of this …
Utility of a multiparametric quantitative MRI model that assesses myelin and edema for evaluating plaques, periplaque white matter, and normal-appearing white …
A Hagiwara, M Hori, K Yokoyama… - American Journal …, 2017 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: T1 and T2 values and proton density can now be
quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can …
quantified on the basis of a single MR acquisition. The myelin and edema in a voxel can …
Comparing MRI metrics to quantify white matter microstructural damage in multiple sclerosis
Quantifying white matter damage in vivo is becoming increasingly important for investigating
the effects of neuroprotective and repair strategies in multiple sclerosis (MS). While various …
the effects of neuroprotective and repair strategies in multiple sclerosis (MS). While various …
[HTML][HTML] Myelin measurement using quantitative magnetic resonance imaging: a correlation study comparing various imaging techniques in patients with multiple …
L Saccenti, A Hagiwara, C Andica, K Yokoyama… - Cells, 2020 - mdpi.com
Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds
promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple …
promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple …
Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy
Quantitative measurement of MRI-defined brain lesions can provide an index of the extent
and activity of disease in multiple sclerosis patients. However, the relationships between …
and activity of disease in multiple sclerosis patients. However, the relationships between …
Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
J O'Muircheartaigh, I Vavasour… - Human Brain …, 2019 - Wiley Online Library
Quantitative magnetic resonance imaging (MRI) techniques have been developed as
imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology …
imaging biomarkers, aiming to improve the specificity of MRI to underlying pathology …
MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis
EN York, SJ Martin, R Meijboom… - Brain …, 2021 - academic.oup.com
Myelin loss is associated with axonal damage in established multiple sclerosis. This
relationship is challenging to study in vivo in early disease. Here, we ask whether myelin …
relationship is challenging to study in vivo in early disease. Here, we ask whether myelin …