A case of low-dose oral methotrexate–induced reversible neurotoxicity

B Paudyal, R Viets, M Skliut - American Journal of …, 2010 - Am Soc Neuroradiology
Methotrexate (MTX) has poor central nervous system penetration as an oral agent. Although
commonly seen with intrathecal dosing, there are only few reports of oral MTXJinduced …

Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome

N Rollins, N Winick, R Bash… - American journal of …, 2004 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Acute lymphocytic leukemia (ALL) is a common
malignancy of childhood treated with methotrexate (MTX), which is associated with acute …

Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke

A Agarwal, K Vijay, K Thamburaj, T Ouyang - Emergency radiology, 2011 - Springer
Methotrexate (MTX) is an indispensable antimetabolite for the treatment of oncological and
immunological disorders in all age groups. It can be administrated intravenously as well as …

Neurotoxicity of intrathecal methotrexate: MR imaging findings

C Sandoval, M Kutscher… - American journal of …, 2003 - Am Soc Neuroradiology
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness
and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion …

Methotrexate leukoencephalopathy mimics acute progressive stroke

R Tanaka, K Sasaki-Ikesawa, H Shimura, K Nishioka… - Journal of …, 2011 - Springer
Stroke mimics are often encountered in emergency departments, and previous studies have
demonstrated that 25.3% of patients diagnosed with acute ischemic stroke are actually …

Diffusion and perfusion imaging in subacute neurotoxicity following high-dose intravenous methotrexate

AF Eichler, TT Batchelor, JW Henson - Neuro-oncology, 2007 - academic.oup.com
Methotrexate (MTX) is a widely used chemotherapeutic agent that can cause acute,
subacute, and chronic neurological complications. Subacute MTX neurotoxicity is manifest …

A unique radiological case of intrathecal methotrexate-induced toxic leukoencephalopathy

J Yang, GS Kim, HM Park - Journal of the Neurological Sciences, 2015 - jns-journal.com
Methotrexate (MTX) is a necessary antimetabolite for the treatment of oncological disorders
in all age groups. It was first introduced in 1948 for treatment of childhood lymphocytic …

Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity

J Balin, H Parmar, L Kujawski - Journal of the neurological sciences, 2008 - Elsevier
We describe longitudinal diffusion-weighted MRI findings of sub-acute leukoencephalopathy
following methotrexate therapy in a 24-year-old man diagnosed with pre-B-cell acute …

Case of methotrexate encephalopathy: findings on diffusion tensor image and correlation with clinical outcome

Y Terasawa, S Nakane, T Ohnishi… - Rinsho Shinkeigaku …, 2007 - europepmc.org
Methotrexate (MTX) is a major cause of treatment-related acute neurotoxicity. We report on
clinical and imaging findings of reversibly restricted diffusion in a patient with transient …

Disseminated necrotizing leukoencephalopathy following low‐dose oral methotrexate

S Raghavendra, MD Nair… - European journal of …, 2007 - Wiley Online Library
Leukoencephalopathy is a recognized complication with intrathecal or intravenous
methotrexate (MTX). We report a 59‐year‐old lady who developed MTX …