Patterning chronic active demyelination in slowly expanding/evolving white matter MS lesions

C Elliott, DL Arnold, H Chen, C Ke… - American Journal …, 2020 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Slowly expanding/evolving lesions measured by
conventional T1-weighted/T2-weighted brain MR imaging may contribute to progressive …

Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis

C Elliott, S Belachew, JS Wolinsky, SL Hauser… - Brain, 2019 - academic.oup.com
Chronic active and slowly expanding lesions with smouldering inflammation are
neuropathological correlates of progressive multiple sclerosis pathology. T1 hypointense …

[HTML][HTML] Imaging of repeated episodes of demyelination and remyelination in multiple sclerosis

RA Brown, S Narayanan, DL Arnold - NeuroImage: Clinical, 2014 - Elsevier
Multiple sclerosis (MS) is characterized by the formation of demyelinating lesions in the
white matter (WM). However, the timecourse of the evolution of healthy white matter into fully …

Early structural changes in acute MS lesions assessed by serial magnetization transfer studies

V Dousset, A Gayou, B Brochet, JM Caille - Neurology, 1998 - AAN Enterprises
Background: Whether acute MS lesions are primarily inflammatory or demyelinative is
unresolved. Our study examined acute MS lesions longitudinally by quantitative …

Analysis of normal-appearing white matter in multiple sclerosis: comparison of diffusion tensor MR imaging and magnetization transfer imaging

AC Guo, VL Jewells… - American journal of …, 2001 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Our purpose was to compare diffusion tensor MR and
magnetization transfer imaging in assessing normal-appearing white matter (WM) regions in …

Abnormalities in normal-appearing white matter from which multiple sclerosis lesions arise

C Elliott, P Momayyezsiahkal, DL Arnold… - Brain …, 2021 - academic.oup.com
Normal-appearing white matter is far from normal in multiple sclerosis; little is known about
the precise pathology or spatial pattern of this alteration and its relation to subsequent lesion …

Characterization of multiple sclerosis plaques with T1-weighted MR and quantitative magnetization transfer.

LA Loevner, RI Grossman… - American journal …, 1995 - Am Soc Neuroradiology
PURPOSE To investigate the relationship between the appearance of multiple sclerosis
lesions identified on unenhanced T1-weighted images and their corresponding …

Serial magnetization transfer imaging to characterize the early evolution of new MS lesions

NC Silver, M Lai, MR Symms, GJ Barker, WI McDonald… - Neurology, 1998 - AAN Enterprises
Objective: To explore the temporal relation of demyelination and blood-brain barrier
breakdown during new lesion formation. Background: Conventional MRI appears sensitive …

Dirty-appearing white matter in multiple sclerosis: volumetric MR imaging and magnetization transfer ratio histogram analysis

Y Ge, RI Grossman, JS Babb, J He… - American Journal of …, 2003 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: In contrast to “normal-appearing” white matter (NAWM) in
patients with multiple sclerosis (MS), there are subtle, abnormal and diffuse signal intensity …

Multiple sclerosis: magnetization transfer histogram analysis of segmented normal-appearing white matter

I Catalaa, RI Grossman, DL Kolson, JK Udupa, LG Nyul… - Radiology, 2000 - pubs.rsna.org
PURPOSE: To investigate and characterize the global distribution of magnetization transfer
(MT) ratio values of normal-appearing white matter (NAWM) in patients with relapsing …