BACKGROUND AND PURPOSE: Along with cortical abnormalities, white matter
microstructural changes such as axonal loss and myelin breakdown are implicated in the …

Post-mortem and imaging studies have observed that white matter (WM) degenerates in a
pattern inverse to myelin development, suggesting preferential regional vulnerabilities …

Myelin breakdown and neural fiber loss occur in aging. This study used white matter tract
integrity metrics derived from biophysical modeling using Diffusional Kurtosis Imaging to …

The pattern of degenerative changes in the brain white matter (WM) in aging, mild cognitive
impairment (MCI), and Alzheimer's disease (AD) has been under debate. Methods of image …

Surrogates of whole-brain white matter (WM) networks reconstructed using diffusion tensor
imaging (DTI) are novel markers of structural brain connectivity. Global connectivity of …

Although much prior work has focused on the known cortical pathology that defines
Alzheimer's disease (AD) histologically, recent work has additionally demonstrated …

Background To determine whether white matter (WM) memory network changes accompany
early cognitive impairment and whether these changes represent early, pathologically …

White matter lesions, quantified as 'white matter signal abnormalities'(WMSA) on
neuroimaging, are common incidental findings on brain images of older adults. This tissue …

Neuroimaging biomarkers that precede cognitive decline have the potential to aid early
diagnosis of Alzheimer's disease (AD). A body of diffusion tensor imaging (DTI) work has …

Alzheimer's disease is increasingly considered a large-scale network disconnection
syndrome, associated with progressive aggregation of pathological proteins, cortical …