BACKGROUND AND PURPOSE: Permeability surface-area product has been suggested as
a marker for BBB permeability with potential applications in clinical care and research …

Background and Purpose—We sought to validate the blood–brain barrier permeability
measurements extracted from perfusion-weighted MRI through a relatively simple and …

Much work has been done in the last several decades to improve the understanding of the
molecular composition of the blood-brain barrier (BBB). Advances in magnetic resonance …

Key points The blood–brain barrier (BBB) is an important and dynamic structure which
contributes to homeostasis in the central nervous system. BBB permeability changes occur …

The blood–brain barrier (BBB) is a functional and structural barrier separating the
intravascular and neuropil compartments of the brain. It characterizes the vascular bed and …

Breakdown of the blood‐brain barrier (BBB), occurring in many neurological diseases, has
been difficult to measure noninvasively in humans. Dynamic contrast‐enhanced magnetic …

OBJECTIVE. Our purpose is to describe methods of assessing leakiness of the blood-brain
barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic …

✓ Hyperosmolar blood-brain barrier (BBB) disruption remains controversial as an adjuvant
therapy to increase delivery of water-soluble compounds to extracellular space in the brain …

Research during the past decade has greatly extended our appreciation of the blood-brain
barrier (BBB) and its functional importance [1–3]. Although disturbance of the barrier has …

The evaluation of blood–brain barrier (BBB) integrity with contrast-enhanced magnetic
resonance imaging (MRI) may prove valuable in the setting of certain brain pathologies …