[PDF][PDF] CT and MR imaging of Canavan disease.

HP McAdams, CA Geyer, SL Done… - American journal …, 1990 - Am Soc Neuroradiology
Discussion Canavan disease, or spongy degeneration of the CNS, usually presents in early
infancy with hypotonia, followed by spasticity, cortical blindness, and megalencephaly [1, 2] …

Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in Canavan's disease: a case report

HG Marks, PA Caro, Z Wang, JA Detre… - Annals of Neurology …, 1991 - Wiley Online Library
The neuroradiological evaluation of Canavan's disease in a 38‐month‐old girl is discussed.
Computed tomography showed diffuse symmetrical low attenuation values of the subcortical …

Canavan disease: CT and MR imaging of the brain.

J Brismar, G Brismar, G Gascon… - American Journal of …, 1990 - Am Soc Neuroradiology
Canavan disease (spongy degeneration of the brain) is a rare lethal neurodegenerative
disorder of infancy; fewer than 100 cases have been reported. We describe a series of nine …

Canavan disease: a review of recent developments

N Gordon - European Journal of Paediatric Neurology, 2001 - Elsevier
The clinical features, causes and potential treatment of Canavan disease are reviewed. The
course of the illness can show considerable variation, and can sometimes be protracted. It …

Magnetic resonance imaging in juvenile Canavan disease

PB Toft, R Geiss-Holtorff, MO Rolland, O Pryds… - European journal of …, 1993 - Springer
We present a 2-year-old boy and a 6-year-old girl with mild Canavan disease (CD).
Aspartoacylase activity in skin fibroblasts was deficient. Magnetic resonance imaging (MRI) …

Biochemical diagnosis of Canavan disease

G Bartalini, M Margollicci, P Balestri, MA Farnetani… - Child's Nervous …, 1992 - Springer
Canavan disease (CD) is a rare autosomal recessive disorder characterized by
macrocephaly and progressive leukodystrophy. Up to now biopsy or necropsy were required …

Restricted diffusion in Canavan disease

SG Srikanth, HS Chandrashekar, K Nagarajan… - Child's Nervous …, 2007 - Springer
Introduction Canavan disease is a megalencephalic leukodystrophy due to deficiency of the
enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-l-aspartate is …

A case of Canavan disease: the first biochemically proven case in a Japanese girl

H Hamaguchi, K Nihei, N Nakamoto, T Ezoe… - Brain and …, 1993 - Elsevier
Canavan disease (CD) has only been diagnosed on autopsy or brain biopsy, however,
specific biochemical markers, such as N-acetylaspartic acid (NAA) and aspartoacylase …

Magnetic resonance tomography and localized proton spectroscopy in 2 siblings with Canavan's disease

V Engelbrecht, M Rassek, J Gärtner… - Rofo: Fortschritte auf …, 1995 - europepmc.org
We present the findings of magnetic resonance imaging (MRI) and localised 1H magnetic
resonance spectroscopy (MRS) in two brothers with Canavan's disease, a rare autosomal …

Spongy degeneration of the brain, Canavan disease: biochemical and molecular findings

R Matalon, K Michals-Matalon - Pediatric Pathology & Molecular …, 1998 - Taylor & Francis
Canavan disease is a severe progressive leukodystrophy characterized by swelling and
spongy degeneration of the white matter of the brain. It is an autosomal recessive disease …