MGMT promoter methylation status in initial and recurrent glioblastoma: correlation study with DWI and DSC PWI features

HJ Choi, SH Choi, SH You, RE Yoo… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: O6-methylguanine-DNA methyltransferase (MGMT)
promoter methylation status in primary and recurrent glioblastoma may change during …

Different diagnostic values of imaging parameters to predict pseudoprogression in glioblastoma subgroups stratified by MGMT promoter methylation

RG Yoon, HS Kim, W Paik, WH Shim, SJ Kim… - European radiology, 2017 - Springer
Objectives The aim of this study was to determine whether diffusion and perfusion imaging
parameters demonstrate different diagnostic values for predicting pseudoprogression …

[HTML][HTML] Structural and advanced imaging in predicting MGMT promoter methylation of primary glioblastoma: a region of interest based analysis

Y Han, LF Yan, XB Wang, YZ Sun, X Zhang, ZC Liu… - BMC cancer, 2018 - Springer
Background The methylation status of oxygen 6-methylguanine-DNA methyltransferase
(MGMT) promoter has been associated with treatment response in glioblastoma (GBM) …

Predictive markers for MGMT promoter methylation in glioblastomas

T Kanazawa, Y Minami, M Jinzaki, M Toda… - Neurosurgical …, 2019 - Springer
The promoter methylation status of the O 6-methylguanine-DNA methyltransferase (MGMT)
gene has been described as the most important predictor of chemotherapeutic response …

Clinically relevant imaging features for MGMT promoter methylation in multiple glioblastoma studies: a systematic review and meta-analysis

CH Suh, HS Kim, SC Jung… - American Journal of …, 2018 - Am Soc Neuroradiology
BACKGROUND: O6-methylguanine methyltransferase (MGMT) promoter methylation status
has been reported as a prognostic biomarker in clinical trials. PURPOSE: Our aim was to …

MGMT promoter methylation in patients with glioblastoma: is methylation-sensitive high-resolution melting superior to methylation-sensitive polymerase chain reaction …

S Yamashita, K Yokogami, F Matsumoto, K Saito… - Journal of …, 2018 - thejns.org
OBJECTIVE The methylation status of the O6-methylguanine-DNA methyltransferase
(MGMT) gene promoter is a prognostic factor in adults with glioblastoma (GBM); it also yields …

Defining the cutoff value of MGMT gene promoter methylation and its predictive capacity in glioblastoma

G Brigliadori, F Foca, M Dall'Agata, C Rengucci… - Journal of neuro …, 2016 - Springer
Despite advances in the treatment of glioblastoma (GBM), median survival is 12–15 months.
O 6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status is …

[HTML][HTML] MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

AB Håvik, P Brandal, H Honne, HSS Dahlback… - Journal of translational …, 2012 - Springer
Background Methylation of the O 6-methylguanine-DNA methyltransferase (MGMT) gene
promoter is a favorable prognostic factor in glioblastoma patients. However, reported …

Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo …

BM Ellingson, TF Cloughesy, WB Pope, TM Zaw… - Neuroimage, 2012 - Elsevier
Promoter methylation of O6-methylguanine DNA methyltransferase (MGMT) is associated
with a favorable prognosis in glioblastoma multiforme (GBM) and has been hypothesized to …

[HTML][HTML] MGMT gene promoter methylation and its correlation with clinicopathological parameters in glioblastomas

I Arora, M Gurav, R Rumde, S Dhanavade… - Neurology …, 2018 - journals.lww.com
Background: MGMT (O 6-methyl guanine DNA methyl transferase) promoter
hypermethylation is a prognostic and predictive biomarker for glioblastomas (GBM). Aims …