Quantitative assessment of brain stem and cerebellar atrophy in spinocerebellar ataxia types 3 and 6: impact on clinical status

L Eichler, B Bellenberg, HK Hahn… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cerebellar and brain stem atrophy are important features
in SCA3, whereas SCA6 has been regarded as a “pure” cerebellar disease. However …

Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6

JB Schulz, J Borkert, S Wolf, T Schmitz-Hübsch… - Neuroimage, 2010 - Elsevier
BACKGROUND AND OBJECTIVE: Biomarkers to monitor neurological dysfunction in
autosomal dominant inherited spinocerebellar ataxias (SCA) are lacking. We therefore …

Spinocerebellar ataxia type 1: one-year longitudinal study to identify clinical and MRI measures of disease progression in patients and presymptomatic carriers

A Nigri, L Sarro, A Mongelli, A Castaldo, L Porcu… - The Cerebellum, 2022 - Springer
Abstract Spinocerebellar ataxias type 1 (SCA1) is an autosomal dominant disease usually
manifesting in adulthood. We performed a prospective 1-year longitudinal study in 14 …

Gray and white matter alterations in spinocerebellar ataxia type 7: an in vivo DTI and VBM study

S Alcauter, FA Barrios, R Díaz, J Fernández-Ruiz - Neuroimage, 2011 - Elsevier
Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder
characterized by cerebellar ataxia and visual loss. It is caused by a CAG repeat expansion …

Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2

K Reetz, R Rodríguez‐Labrada, I Dogan… - Annals of clinical …, 2018 - Wiley Online Library
Objective Spinocerebellar ataxia type 2 (SCA 2) is an autosomal dominantly inherited
neurodegenerative disease mainly affecting the cerebellum and brainstem. In this Cuban …

[HTML][HTML] Progression of cerebellar atrophy in spinocerebellar ataxia type 2 gene carriers: a longitudinal MRI study in preclinical and early disease stages

A Nigri, L Sarro, A Mongelli, C Pinardi, L Porcu… - Frontiers in …, 2020 - frontiersin.org
Spinocerebellar ataxias type 2 (SCA2) is an autosomal dominant inherited disease caused
by expanded trinucleotide repeats (≥ 32 CAG) within the coding region of ATXN2 gene …

Genotype-specific patterns of atrophy progression are more sensitive than clinical decline in SCA1, SCA3 and SCA6

K Reetz, AS Costa, S Mirzazade, A Lehmann, A Juzek… - Brain, 2013 - academic.oup.com
Spinocerebellar ataxias are dominantly inherited disorders that are associated with
progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of …

Brain structural damage in spinocerebellar ataxia type 1: a VBM study

A Ginestroni, R Della Nave, C Tessa, M Giannelli… - Journal of …, 2008 - Springer
Background and objective Neuropathological description of the brain in spinocerebellar
ataxia type 1 (SCA1) is limited to a few cases. Voxel-based morphometry (VBM) enables an …

Spinal cord atrophy in spinocerebellar ataxia type 3 and 6: impact on clinical disability

C Lukas, HK Hahn, B Bellenberg, K Hellwig… - Journal of …, 2008 - Springer
Objective To quantify spinal cord atrophy and its impact on clinical disability in
spinocerebellar ataxia (SCA) type 3 and 6. Methods Atrophy of the upper spinal cord was …

Dissociation of grey and white matter reduction in spinocerebellar ataxia type 3 and 6: a voxel-based morphometry study

C Lukas, L Schöls, B Bellenberg, U Rüb, H Przuntek… - Neuroscience …, 2006 - Elsevier
The aim of this study was to examine the different patterns of cerebellar and/or brainstem
atrophy in spinocerebellar ataxia (SCA) type 3 and 6. Eighteen patients (SCA3 n= 9, SCA6 …