White matter alterations in the brains of patients with active, remitted, and cured Cushing syndrome: a DTI study

P Pires, A Santos, Y Vives-Gilabert… - American Journal …, 2015 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cushing syndrome appears after chronic exposure to
elevated glucocorticoid levels. Cortisol excess may alter white matter microstructure. Our …

Altered gray and white matter microstructure in Cushing's disease: A diffusional kurtosis imaging study

H Jiang, NY He, YH Sun, FF Jian, LG Bian, JK Shen… - Brain research, 2017 - Elsevier
Exposure to chronic hypercortisolism has multiple adverse effects on brain biology in
humans. Cushing's disease (CD) represents a unique and natural human model for …

Volumetric magnetic resonance imaging analysis in patients with short‐term remission of Cushing's disease

H Jiang, J Ren, NY He, C Liu, YH Sun… - Clinical …, 2017 - Wiley Online Library
Objective The data on patients with short‐term remission of Cushing's disease (CD) might
provide information that is not available from previous long‐term remission studies. We …

[HTML][HTML] Widespread reductions of white matter integrity in patients with long-term remission of Cushing's disease

SJA van der Werff, CD Andela, JN Pannekoek… - NeuroImage: Clinical, 2014 - Elsevier
Background Hypercortisolism leads to various physical, psychological and cognitive
symptoms, which may partly persist after the treatment of Cushing's disease. The aim of the …

White matter involvement on DTI-MRI in Cushing's syndrome relates to mood disturbances and processing speed: a case-control study

P Pires, A Santos, Y Vives-Gilabert, SM Webb… - Pituitary, 2017 - Springer
Purpose Cushing's syndrome (CS) is an endocrine disorder due to prolonged exposure to
cortisol. Recently, microstructural white matter (WM) alterations detected by diffusion tensor …

Smaller grey matter volumes in the anterior cingulate cortex and greater cerebellar volumes in patients with long-term remission of Cushing's disease: a case–control …

CD Andela, SJA van der Werff… - European Journal of …, 2013 - academic.oup.com
Objective Patients with long-term remission of Cushing's disease (CD) have persistent
psychological and cognitive impairments. It is unknown whether, and to what extent, these …

Reversible and the irreversible structural alterations on brain after resolution of hypercortisolism in Cushing's disease

H Jiang, C Liu, SJ Pan, J Ren, NY He, YH Sun, LG Bian… - Steroids, 2019 - Elsevier
The adverse effects of hypercortisolism on the human brain have been highlighted in
previous studies of Cushing's disease (CD). However, the reversibility of brain damage after …

Cerebral atrophy in Cushing's disease

NE Simmons, HM Do, MH Lipper, ER Laws Jr - Surgical neurology, 2000 - Elsevier
BACKGROUND Cushing's disease causes significant pathological changes throughout the
body as a result of elevated cortisol levels. Very few systematic investigations have focused …

Cardiovascular risk and white matter lesions after endocrine control of Cushing's syndrome

A Santos, E Resmini, B Gomez-Anson… - European Journal of …, 2015 - academic.oup.com
Objective Cushing's syndrome (CS) is associated with high cardiovascular risk. White matter
lesions (WML) are common on brain magnetic resonance imaging (MRI) in patients with …

Computerized analysis of brain MRI parameter dynamics in young patients with Cushing syndrome—a case-control study

A Tirosh, H RaviPrakash, GZ Papadakis… - The Journal of …, 2020 - academic.oup.com
Abstract Background Young patients with Cushing Syndrome (CS) may develop cognitive
and behavioral alterations during disease course. Methods To investigate the effects of CS …