Glioma angiogenesis and perfusion imaging: understanding the relationship between tumor blood volume and leakiness with increasing glioma grade

R Jain, B Griffith, F Alotaibi, D Zagzag… - American Journal …, 2015 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The purpose of this study was to investigate imaging
correlates to the changes occurring during angiogenesis in gliomas. This was accomplished …

Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade

R Jain, SK Ellika, L Scarpace… - American Journal …, 2008 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Glioma angiogenesis and its different hemodynamic
features, which can be evaluated by using perfusion CT (PCT) imaging of the brain, have …

In vivo correlation of tumor blood volume and permeability with histologic and molecular angiogenic markers in gliomas

R Jain, J Gutierrez, J Narang… - American Journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Tumor angiogenesis is very heterogeneous and in vivo
correlation of perfusion imaging parameters with angiogenic markers can help in better …

Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging

B Ding, HW Ling, KM Chen, H Jiang, YB Zhu - Neuroradiology, 2006 - Springer
Introduction Regional cerebral blood volume (rCBV) and permeability surfaces (rPS) permit
in vivo assessment of glioma microvasculature, which provides quite important …

Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity

JM Lupo, S Cha, SM Chang… - American Journal of …, 2005 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The advent of new anti-angiogenic therapies has created
the need for better defining regions of abnormal vascularity in order to add specificity to the …

Role of perfusion CT in glioma grading and comparison with conventional MR imaging features

SK Ellika, R Jain, SC Patel… - American Journal …, 2007 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Perfusion imaging using CT can provide additional
information about tumor vascularity and angiogenesis for characterizing gliomas. The …

Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast-enhanced perfusion MR imaging with glioma grade

M Law, S Yang, JS Babb, EA Knopp… - American Journal …, 2004 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Relative cerebral blood volume (rCBV) and vascular
permeability (Ktrans) permit in vivo assessment of glioma microvasculature. We assessed …

Prognostic vascular imaging biomarkers in high-grade gliomas: tumor permeability as an adjunct to blood volume estimates

R Jain, J Narang, B Griffith, H Bagher-Ebadian… - Academic radiology, 2013 - Elsevier
RATIONALE AND OBJECTIVES: Despite recent advances in the treatment of high-grade
gliomas, overall survival (OS) remains poor, which underlines the importance of searching …

Survival prediction in high-grade gliomas using CT perfusion imaging

TPC Yeung, Y Wang, W He, B Urbini, R Gafà… - Journal of neuro …, 2015 - Springer
Patients with high-grade gliomas usually have heterogeneous response to surgery and
chemoirradiation. The objectives of this study were (1) to evaluate serial changes in tumor …

Abnormalities in the recirculation phase of contrast agent bolus passage in cerebral gliomas: comparison with relative blood volume and tumor grade

A Jackson, A Kassner… - American journal …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Abnormalities in the recirculation phase of the passage of
a contrast agent bolus have been identified in tumors and have been suggested to represent …