Measuring glymphatic flow in man using quantitative contrast-enhanced MRI

R Watts, JM Steinklein, L Waldman… - American Journal of …, 2019 - Am Soc Neuroradiology
On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in
the development of Alzheimer's disease. We report the first quantitative study of glymphatic …

MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain

PK Eide, G Ringstad - Acta radiologica open, 2015 - journals.sagepub.com
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a
paravascular, transparenchymal route for clearance of excess brain metabolites and …

Glymphatic MRI in idiopathic normal pressure hydrocephalus

G Ringstad, SAS Vatnehol, PK Eide - Brain, 2017 - academic.oup.com
The glymphatic system has in previous studies been shown as fundamental to clearance of
waste metabolites from the brain interstitial space, and is proposed to be instrumental in …

Intrathecal use of gadobutrol for glymphatic MR imaging: prospective safety study of 100 patients

CS Edeklev, M Halvorsen, G Løvland… - American Journal …, 2019 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Intrathecal contrast-enhanced glymphatic MR imaging has
shown promise in assessing glymphatic function in patients with dementia. The purpose of …

Glymphatics visualization after focused ultrasound‐induced blood–brain barrier opening in humans

Y Meng, A Abrahao, CC Heyn, AJ Bethune… - Annals of …, 2019 - Wiley Online Library
It is currently unclear whether the glymphatic system, a brain‐wide interstitial fluid–
cerebrospinal fluid exchange described in rodents, exists in humans. Focal blood–brain …

Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function

SB Richmond, S Rane, MR Hanson… - European Journal of …, 2023 - Wiley Online Library
The glymphatic system is a brain‐wide network of perivascular pathways along which
cerebrospinal fluid and interstitial fluid rapidly exchange, facilitating solute and waste …

MRI investigation of glymphatic responses to Gd‐DTPA infusion rates

G Ding, M Chopp, L Li, L Zhang… - Journal of …, 2018 - Wiley Online Library
The glymphatic system is a newly identified waste clearance pathway in brain discovered
and investigated predominately using in vivo two‐photon confocal microscopy. Magnetic …

Glymphatic pathway of gadolinium-based contrast agents through the brain: overlooked and misinterpreted

K Deike-Hofmann, J Reuter, R Haase… - Investigative …, 2019 - journals.lww.com
Background The “glymphatic system”(GS), a brain-wide network of cerebrospinal fluid
microcirculation, supplies a pathway through and out of the central nervous system (CNS); …

Glymphatic imaging using MRI

T Taoka, S Naganawa - Journal of Magnetic Resonance …, 2020 - Wiley Online Library
In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid
(CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system …

Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's …

T Taoka, Y Masutani, H Kawai, T Nakane… - Japanese journal of …, 2017 - Springer
Purpose The activity of the glymphatic system is impaired in animal models of Alzheimer's
disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with …