PURPOSE To determine whether osmotic blood-brain barrier disruption is associated with
MR abnormalities or cognitive deterioration and, if so, whether the MR findings correlate with …

Results of initial clinical trials of brain tumor chemotherapy after osmotic blood-brain barrier
disruption are promising. In general, the procedure is well tolerated. The major complication …

Object. Osmotic blood—brain barrier (BBB) disruption induced by intraarterial infusion of
mannitol is used in conjunction with chemotherapy to treat human brain tumors. The time …

Chemotherapeutic drug delivery can be enhanced by administering drugs into the internal
carotid or vertebral artery circulation after osmotic opening of the blood-brain barrier (BBB) …

Compared to the conventional mode of chemotherapy of malignant brain gliomas following
surgery and radiation therapy, chemotherapy after transient disruption of the blood-brain …

Enhanced computerized tomography (CT) is a noninvasive means of monitoring blood-brain
barrier (BBB) disruption. In the present study this technique was used to monitor the degree …

Three patients with primary central nervous system (CNS) lymphoma have had major tumor
regression with multiagent chemotherapy given in association with reversible blood-brain …

The blood-brain barrier seems to be an important factor in drug access to malignant brain
tumors. Successful experimental reversible disruption of the blood-brain barrier in animals …

Blood-brain barrier disruption with a hyperosmolar agent, mannitol, has previously been
demonstrated to increase intracerebral methotrexate levels in rats. To determine the …

The blood-brain barrier (BBB) is a paradox. On one hand, it protects the brain from what
would otherwise be a constant systemic barrage of noxious substances. On the other hand …