MR and cognitive testing of patients undergoing osmotic blood-brain barrier disruption with intraarterial chemotherapy.
S Roman-Goldstein, P Mitchell… - American journal …, 1995 - Am Soc Neuroradiology
PURPOSE To determine whether osmotic blood-brain barrier disruption is associated with
MR abnormalities or cognitive deterioration and, if so, whether the MR findings correlate with …
MR abnormalities or cognitive deterioration and, if so, whether the MR findings correlate with …
Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning
EA Neuwelt, HD Specht, J Howieson… - American journal of …, 1983 - Am Roentgen Ray Soc
Results of initial clinical trials of brain tumor chemotherapy after osmotic blood-brain barrier
disruption are promising. In general, the procedure is well tolerated. The major complication …
disruption are promising. In general, the procedure is well tolerated. The major complication …
In vivo assessment of the window of barrier opening after osmotic blood—brain barrier disruption in humans
T Siegal, R Rubinstein, F Bokstein, A Schwartz… - Journal of …, 2000 - thejns.org
Object. Osmotic blood—brain barrier (BBB) disruption induced by intraarterial infusion of
mannitol is used in conjunction with chemotherapy to treat human brain tumors. The time …
mannitol is used in conjunction with chemotherapy to treat human brain tumors. The time …
Osmotic blood-brain barrier modification and combination chemotherapy: concurrent tumor regression in areas of barrier opening and progression in brain regions …
EA Neuwelt, SA Hill, EP Frenkel - Neurosurgery, 1984 - journals.lww.com
Chemotherapeutic drug delivery can be enhanced by administering drugs into the internal
carotid or vertebral artery circulation after osmotic opening of the blood-brain barrier (BBB) …
carotid or vertebral artery circulation after osmotic opening of the blood-brain barrier (BBB) …
Radionuclide assessment of blood-brain barrier disruption performed for chemotherapy of high grade malignant brain gliomas
A Singh, BD Belshe, MK Gumerlock - … Part B. Nuclear medicine and biology, 1991 - Elsevier
Compared to the conventional mode of chemotherapy of malignant brain gliomas following
surgery and radiation therapy, chemotherapy after transient disruption of the blood-brain …
surgery and radiation therapy, chemotherapy after transient disruption of the blood-brain …
Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption
EA Neuwelt, KR Maravilla, EP Frenkel, P Barnett… - …, 1980 - journals.lww.com
Enhanced computerized tomography (CT) is a noninvasive means of monitoring blood-brain
barrier (BBB) disruption. In the present study this technique was used to monitor the degree …
barrier (BBB) disruption. In the present study this technique was used to monitor the degree …
Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood-brain barrier opening
EA Neuwelt, E Balaban, J Diehl, S Hill, E Frenkel - Neurosurgery, 1983 - journals.lww.com
Three patients with primary central nervous system (CNS) lymphoma have had major tumor
regression with multiagent chemotherapy given in association with reversible blood-brain …
regression with multiagent chemotherapy given in association with reversible blood-brain …
Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors
EA Neuwelt, EP Frenkel, J Diehl, LH Vu… - …, 1980 - journals.lww.com
The blood-brain barrier seems to be an important factor in drug access to malignant brain
tumors. Successful experimental reversible disruption of the blood-brain barrier in animals …
tumors. Successful experimental reversible disruption of the blood-brain barrier in animals …
Blood-brain barrier disruption using mannitol: time course and electron microscopy studies
WC Cosolo, P Martinello, WJ Louis… - American Journal of …, 1989 - journals.physiology.org
Blood-brain barrier disruption with a hyperosmolar agent, mannitol, has previously been
demonstrated to increase intracerebral methotrexate levels in rats. To determine the …
demonstrated to increase intracerebral methotrexate levels in rats. To determine the …
Advances in the understanding of the blood-brain barrier in neuro-oncology
RM Quencer, EA Neuwelt - American Journal of …, 2002 - Am Soc Neuroradiology
The blood-brain barrier (BBB) is a paradox. On one hand, it protects the brain from what
would otherwise be a constant systemic barrage of noxious substances. On the other hand …
would otherwise be a constant systemic barrage of noxious substances. On the other hand …
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