BACKGROUND AND PURPOSE: ALS is predominantly a disease of the motor system, but
cognitive and behavioral symptoms also are observed. DT MR imaging is sensitive to …

BACKGROUND AND PURPOSE: Most DTI studies in ALS have been limited to the
assessment of the CST damage. In this study, we used DTI tractography to investigate …

BACKGROUND AND PURPOSE: ALS leads to macrostructural (ie, cortical atrophy and
hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic …

Background A relevant fraction of patients with amyotrophic lateral sclerosis (ALS) exhibit a
fronto-temporal pattern of cognitive and behavioural disturbances with pronounced deficits …

Our objective was to quantify and better understand white matter (WM) impairment in
patients with amyotrophic lateral sclerosis (ALS) and to propose a model based on diffusion …

Purpose To determine if decline in corpus callosum (CC) white matter integrity in patients
with amyotrophic lateral sclerosis (ALS) is localized to motor‐related areas. Materials and …

Our aim was to evaluate the location and extent of white matter involvement in patients with
amyotrophic lateral sclerosis (ALS) using diffusion-tensor magnetic resonance imaging …

The aim of this study was to investigate the extent of cortical and subcortical lesions in
amyotrophic lateral sclerosis (ALS) using, in combination, voxel based diffusion tensor …

Introduction: Executive dysfunction occurs in many patients with amyotrophic lateral
sclerosis (ALS), but it has not been well studied in primary lateral sclerosis (PLS). The aims …

Whether longitudinal diffusion tensor MRI imaging (DTI) can capture disease progression in
patients with amyotrophic lateral sclerosis (ALS) is unclear. The primary goal of this study …