Emerging insights into the molecular and cellular basis of glioblastoma
- Gavin P. Dunn1,2,3,
- Mikael L. Rinne2,3,4,
- Jill Wykosky5,
- Giannicola Genovese2,
- Steven N. Quayle2,
- Ian F. Dunn6,
- Pankaj K. Agarwalla1,2,3,
- Milan G. Chheda2,3,7,
- Benito Campos8,
- Alan Wang9,
- Cameron Brennan10,
- Keith L. Ligon11,
- Frank Furnari5,12,
- Webster K. Cavenee5,
- Ronald A. Depinho9,
- Lynda Chin13 and
- William C. Hahn2,3,14
- 1Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA;
- 2Department of Medical Oncology, Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA;
- 3Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA;
- 4Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;
- 5Ludwig Institute for Cancer Research, University of California at San Diego School of Medicine, La Jolla, California 92093-0660, USA;
- 6Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;
- 7Department of Neurology, the Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA;
- 8Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany;
- 9Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;
- 10Department of Neurosurgery, the Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA;
- 11Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA;
- 12Department of Pathology, University of California at San Diego, La Jolla, California 92093-0660, USA;
- 13Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Abstract
Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that “glioblastoma” represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.
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↵14 Corresponding author.
E-mail william_hahn{at}dfci.harvard.edu.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.187922.112.
- Copyright © 2012 by Cold Spring Harbor Laboratory Press
