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Abstract

Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats.

M E Moseley, J Kucharczyk, J Mintorovitch, Y Cohen, J Kurhanewicz, N Derugin, H Asgari and D Norman
American Journal of Neuroradiology May 1990, 11 (3) 423-429;
M E Moseley
Department of Radiology, University of California, San Francisco 94143.
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J Kucharczyk
Department of Radiology, University of California, San Francisco 94143.
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J Mintorovitch
Department of Radiology, University of California, San Francisco 94143.
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Y Cohen
Department of Radiology, University of California, San Francisco 94143.
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J Kurhanewicz
Department of Radiology, University of California, San Francisco 94143.
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N Derugin
Department of Radiology, University of California, San Francisco 94143.
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H Asgari
Department of Radiology, University of California, San Francisco 94143.
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D Norman
Department of Radiology, University of California, San Francisco 94143.
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Abstract

We evaluated the temporal and anatomic relationships between changes in diffusion-weighted MR image signal intensity, induced by unilateral occlusion of the middle cerebral artery in cats, and tissue perfusion deficits observed in the same animals on T2-weighted MR images after administration of a nonionic intravascular T2 shortening agent. Diffusion-weighted images obtained with strong diffusion-sensitizing gradient strengths (5.6 gauss/cm, corresponding to gradient attenuation factor, b, values of 1413 sec/mm2) displayed increased signal intensity in the ischemic middle cerebral artery territory less than 1 hr after occlusion, whereas T2-weighted images without contrast usually failed to detect injury for 2-3 hr after stroke. After contrast administration (0.5-1.0 mmol/kg by Dy-DTPA-BMA, IV), however, T2-weighted images revealed perfusion deficits (relative hyperintensity) within 1 hr after middle cerebral artery occlusion that corresponded closely to the anatomic regions of ischemic injury shown on diffusion-weighted MR images. Close correlations were also found between early increases in diffusion-weighted MR image signal intensity and disrupted phosphorus-31 and proton metabolite levels evaluated with surface coil MR spectroscopy, as well as with postmortem histopathology. These data indicate that diffusion-weighted MR images more accurately reflect early-onset pathophysiologic changes induced by acute cerebral ischemia than do T2-weighted spin-echo images.

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American Journal of Neuroradiology
Vol. 11, Issue 3
1 May 1990
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Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats.
M E Moseley, J Kucharczyk, J Mintorovitch, Y Cohen, J Kurhanewicz, N Derugin, H Asgari, D Norman
American Journal of Neuroradiology May 1990, 11 (3) 423-429;

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Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats.
M E Moseley, J Kucharczyk, J Mintorovitch, Y Cohen, J Kurhanewicz, N Derugin, H Asgari, D Norman
American Journal of Neuroradiology May 1990, 11 (3) 423-429;
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