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Abstract

Brain atrophy in 18 patients with Down syndrome: a CT study.

G D Pearlson, A C Warren, S E Starkstein, E H Aylward, A J Kumar, G A Chase and M F Folstein
American Journal of Neuroradiology July 1990, 11 (4) 811-816;
G D Pearlson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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A C Warren
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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S E Starkstein
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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E H Aylward
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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A J Kumar
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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G A Chase
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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M F Folstein
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21205.
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Abstract

Individuals with Down syndrome develop neuropathologic and in some cases clinical evidence of Alzheimer disease after age 40. We compared CT scans of 18 Down syndrome subjects, 26-70 years old (seven of whom satisfied criteria for dementia), with 175 screened normal volunteer control subjects for evidence of cortical and subcortical atrophy. CT scans were analyzed as a function of age and cognitive status. The suprasellar cistern ratio, presumed to measure mesial temporal-lobe atrophy (or hypoplasia), was correlated with severity of cognitive impairment, even when age effects were removed. The suprasellar cistern ratio predicted dementia status with an accuracy of greater than 75%. Brain measurements on CT scans showed a distinct pattern of increased abnormality with age in patients with Down syndrome; this differed clearly from that seen in controls.

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American Journal of Neuroradiology
Vol. 11, Issue 4
1 Jul 1990
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Brain atrophy in 18 patients with Down syndrome: a CT study.
G D Pearlson, A C Warren, S E Starkstein, E H Aylward, A J Kumar, G A Chase, M F Folstein
American Journal of Neuroradiology Jul 1990, 11 (4) 811-816;

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Brain atrophy in 18 patients with Down syndrome: a CT study.
G D Pearlson, A C Warren, S E Starkstein, E H Aylward, A J Kumar, G A Chase, M F Folstein
American Journal of Neuroradiology Jul 1990, 11 (4) 811-816;
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