Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Abstract

In vivo MR evaluation of age-related increases in brain iron.

G Bartzokis, J Mintz, D Sultzer, P Marx, J S Herzberg, C K Phelan and S R Marder
American Journal of Neuroradiology June 1994, 15 (6) 1129-1138;
G Bartzokis
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J Mintz
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D Sultzer
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P Marx
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J S Herzberg
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C K Phelan
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S R Marder
Research Service, West Los Angeles VA Medical Center, CA 90073.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

PURPOSE To assess the validity of an MR method of evaluating tissue iron.

METHODS The difference between the transverse relaxation rate (R2) measured with a high-field MR instrument and the R2 measured with a lower field instrument defines a measure termed the field-dependent R2 increase (FDRI). Previous in vivo and in vitro studies indicated that FDRI is a specific measure of tissue iron stores (ferritin). T2 relaxation times were obtained using two clinical MR instruments operating at 0.5 T and 1.5 T. T2 relaxation times were measured in the frontal white matter, caudate nucleus, putamen, and globus pallidus of 20 healthy adult male volunteers with an age range of 20 to 81 years. R2 was calculated as the reciprocal of T2 relaxation time. These in vivo MR results were correlated with previously published postmortem data on age-related increases of nonheme iron levels.

RESULTS The FDRI was very highly correlated with published brain iron levels for the four regions examined. In the age range examined, robust and highly significant age-related increases in FDRI were observed in the caudate and putamen. The correlations of age and FDRI in the globus pallidus and white matter were significantly lower and did not have statistical significance.

CONCLUSIONS The data provide additional evidence that FDRI is a specific measure of tissue iron stores. The data also show that age-related increases in tissue iron stores can be quantified in vivo despite significant age-related processes that oppose the increase in R2 caused by iron. These results are relevant to the investigation of neurodegenerative processes in which iron may catalyze toxic free-radical reactions.

  • Copyright © American Society of Neuroradiology
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 15, Issue 6
1 Jun 1994
  • Table of Contents
  • Index by author
Advertisement
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
In vivo MR evaluation of age-related increases in brain iron.
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
In vivo MR evaluation of age-related increases in brain iron.
G Bartzokis, J Mintz, D Sultzer, P Marx, J S Herzberg, C K Phelan, S R Marder
American Journal of Neuroradiology Jun 1994, 15 (6) 1129-1138;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
In vivo MR evaluation of age-related increases in brain iron.
G Bartzokis, J Mintz, D Sultzer, P Marx, J S Herzberg, C K Phelan, S R Marder
American Journal of Neuroradiology Jun 1994, 15 (6) 1129-1138;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Aging is associated with increased brain iron through brain-derived hepcidin expression
  • Predicting age from cortical structure across the lifespan
  • Transition into Driven Equilibrium of the Balanced Steady-State Free Precession as an Ultrafast Multisection T2-Weighted Imaging of the Brain
  • Different Iron-Deposition Patterns of Multiple System Atrophy with Predominant Parkinsonism and Idiopathetic Parkinson Diseases Demonstrated by Phase-Corrected Susceptibility-Weighted Imaging
  • Labeling of Cerebral Amyloid {beta} Deposits In Vivo Using Intranasal Basic Fibroblast Growth Factor and Serum Amyloid P Component in Mice
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire