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Abstract

The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis.

M W Tas, F Barkhol, M A van Walderveen, C H Polman, O R Hommes and J Valk
American Journal of Neuroradiology February 1995, 16 (2) 259-264;
M W Tas
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F Barkhol
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M A van Walderveen
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C H Polman
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O R Hommes
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J Valk
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Abstract

PURPOSE To determine whether gadolinium can improve the sensitivity and specificity of MR imaging for the initial diagnosis of multiple sclerosis.

METHODS Patients (n = 57) with neurologic symptoms suggesting multiple sclerosis were studied prospectively. MR imaging consisted of T2-weighted and gadolinium-enhanced T1-weighted spin-echo images. Lumbar puncture was performed for cerebrospinal fluid analysis in 34 patients.

RESULTS After imaging, 17 patients (35%) had clinically definite multiple sclerosis. Cerebrospinal fluid examination had a sensitivity of 69% and specificity of 38%. Using liberal criteria, the sensitivity of T2-weighted MR imaging was 94% and the specificity 55%; using more strict criteria, the specificity increased to 65% with a sensitivity of 88%. Gadopentetate dimeglumine enhancement increased the specificity further to 80% with a loss of sensitivity (59%).

CONCLUSION Gadolinium enhancement increases the specificity of MR imaging in the early diagnosis of multiple sclerosis.

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American Journal of Neuroradiology
Vol. 16, Issue 2
1 Feb 1995
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The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis.
M W Tas, F Barkhol, M A van Walderveen, C H Polman, O R Hommes, J Valk
American Journal of Neuroradiology Feb 1995, 16 (2) 259-264;

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The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis.
M W Tas, F Barkhol, M A van Walderveen, C H Polman, O R Hommes, J Valk
American Journal of Neuroradiology Feb 1995, 16 (2) 259-264;
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