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Abstract

Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers.

A B Anderson, T H Tran, M J Hamilton, S J Chudzik, B P Hastings, M J Melchior and R W Hergenrother
American Journal of Neuroradiology May 1996, 17 (5) 859-863;
A B Anderson
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T H Tran
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M J Hamilton
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S J Chudzik
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B P Hastings
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M J Melchior
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R W Hergenrother
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Abstract

The blood-contacting properties of polyethylene coated with a lubricious hydrophilic coating; an uncoated polyethylene; or a photoheparin-treated polyethylene-negative control sample were compared by measuring fibrinogen adsorption, antifibrinogen binding, and platelet attachment from human plasma. The polyethylene surfaces coated with a hydrophilic polymer were found to be similar to surfaces coated with heparin. Fibrinogen adsorption on the hydrophilic coating was 60% lower than adsorption on either the uncoated or heparin-coated polyethylene samples. Antifibrinogen binding from buffer to the hydrophilic coating was also reduced more than 85% from binding to uncoated polyethylene samples. Both the hydrophilic coating and heparin coating showed a reduction in platelet attachment by a factor of 100 over the uncoated sample as well as significantly reduced platelet activation.

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American Journal of Neuroradiology
Vol. 17, Issue 5
1 May 1996
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A B Anderson, T H Tran, M J Hamilton, S J Chudzik, B P Hastings, M J Melchior, R W Hergenrother
Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers.
American Journal of Neuroradiology May 1996, 17 (5) 859-863;

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Platelet deposition and fibrinogen binding on surfaces coated with heparin or friction-reducing polymers.
A B Anderson, T H Tran, M J Hamilton, S J Chudzik, B P Hastings, M J Melchior, R W Hergenrother
American Journal of Neuroradiology May 1996, 17 (5) 859-863;
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