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Abstract

Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.

J H Hwang, G F Egnaczyk, E Ballard, R S Dunn, S K Holland and W S Ball
American Journal of Neuroradiology March 1998, 19 (3) 535-540;
J H Hwang
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G F Egnaczyk
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E Ballard
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R S Dunn
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S K Holland
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W S Ball Jr
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Abstract

PURPOSE We report the common characteristics of juvenile pilocytic astrocytomas revealed by proton MR spectroscopy.

METHODS Eight children with pilocytic astrocytomas were studied with proton MR spectroscopy. The selected sampling volume was approximately 4 cm3, obtained from solid tumor. To localize the sampling volume, we used point-resolved spectroscopy (PRESS) and stimulated-echo acquisition mode (STEAM) techniques to acquire long- and short-TE spectra, respectively. Spectra from PRESS and STEAM sequences were processed using Lorentzian-to-Gaussian transformation and exponential apodization, respectively. For PRESS (2000/270) spectra, peaks of creatine, choline, N-acetylaspartate (NAA), and lactate resonances were integrated; for STEAM (2000/20) spectra, we measured the amplitude of the peaks at 3.2, 2.0, 1.3 and 0.9 ppm.

RESULTS An elevated lactate doublet was observed in the PRESS spectra. The choline/NAA ratio was 3.40. The amplitude ratios of the lipid pattern (0.9, 1.3 and 2.0 ppm) to choline were all below one.

CONCLUSION Despite the benign histology of the tumor, which generally lacks necrosis, a lactate signal was detected in all eight patients studied. A dominant lipid pattern was not observed.

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American Journal of Neuroradiology
Vol. 19, Issue 3
1 Mar 1998
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Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.
J H Hwang, G F Egnaczyk, E Ballard, R S Dunn, S K Holland, W S Ball
American Journal of Neuroradiology Mar 1998, 19 (3) 535-540;

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Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.
J H Hwang, G F Egnaczyk, E Ballard, R S Dunn, S K Holland, W S Ball
American Journal of Neuroradiology Mar 1998, 19 (3) 535-540;
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  • Comparison of Perfusion, Diffusion, and MR Spectroscopy between Low-Grade Enhancing Pilocytic Astrocytomas and High-Grade Astrocytomas
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