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Research ArticleBRAIN

Dynamic Contrast-enhanced T2*-weighted MR Imaging of Tumefactive Demyelinating Lesions

Soonmee Cha, Sean Pierce, Edmond A. Knopp, Glyn Johnson, Clement Yang, Anthony Ton, Andrew W. Litt and David Zagzag
American Journal of Neuroradiology June 2001, 22 (6) 1109-1116;
Soonmee Cha
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Sean Pierce
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Edmond A. Knopp
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Glyn Johnson
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Clement Yang
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Anthony Ton
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Andrew W. Litt
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David Zagzag
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    fig 1.

    TDL in a 22-year-old woman.

    A, Contrast-enhanced T1-weighted image (600/14/1) shows a well-circumscribed solidly enhancing mass in the right frontal lobe.

    B, Fluid-attenuated inversion recovery image (9000/110/1) shows a mild degree of signal abnormality around the lesion.

    C, Color overlay of rCBV map shows no evidence of increased blood volume.

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    fig 2.

    Glioblastoma multiforme in a 63-year-old woman.

    A, Contrast-enhanced T1-weighted image (600/14/1) shows a well-circumscribed mass in the left frontal lobe.

    B, T2-weighted image (3400/119/1) shows minimal edema and mass effect.

    C, Color overlay of rCBV map shows marked increase in blood volume.

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    fig 3.

    TDL in a 37-year-old man.

    A, T2-weighted image (3400/119/1) shows a large hyperintense mass lesion in the right parietal lobe. There are no visible flow voids within the lesion.

    B, Unenhanced T1-weighted image (600/14/1) shows hypointense signal of the lesion.

    C, Contrast-enhanced T1-weighted image (600/14/1) shows heterogeneous enhancement of the medial aspect of the lesion in a concentric pattern.

    D, Dynamic T2*-weighted image (1000/54/1) obtained before IV administration of contrast agent.

    E, Dynamic T2*-weighted image (1000/54/1) obtained during IV administration of contrast agent shows several periventricular, linear vessel-like structures (arrows) running through the center of the lesion near a dilated subependymal vein. The dominant lesion itself shows no signal loss.

    F, Dynamic T2*-weighted image (1000/54/1) obtained 50 s after IV administration of contrast agent shows return of brain signal to baseline, with residual signal loss within the aforementioned linear vessel-like structures.

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    TABLE 1:

    Comparison of rCBV in TDL and intracranial neoplasms

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    TABLE 2:

    Pathologic diagnosis and relative cerebral blood volume measurements of patients with intracranial neoplasms

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American Journal of Neuroradiology: 22 (6)
American Journal of Neuroradiology
Vol. 22, Issue 6
1 Jun 2001
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Dynamic Contrast-enhanced T2*-weighted MR Imaging of Tumefactive Demyelinating Lesions
Soonmee Cha, Sean Pierce, Edmond A. Knopp, Glyn Johnson, Clement Yang, Anthony Ton, Andrew W. Litt, David Zagzag
American Journal of Neuroradiology Jun 2001, 22 (6) 1109-1116;

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Dynamic Contrast-enhanced T2*-weighted MR Imaging of Tumefactive Demyelinating Lesions
Soonmee Cha, Sean Pierce, Edmond A. Knopp, Glyn Johnson, Clement Yang, Anthony Ton, Andrew W. Litt, David Zagzag
American Journal of Neuroradiology Jun 2001, 22 (6) 1109-1116;
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Cited By...

  • MRI Findings in Tumefactive Demyelinating Lesions: A Systematic Review and Meta-Analysis
  • Combining Diffusion Tensor Metrics and DSC Perfusion Imaging: Can It Improve the Diagnostic Accuracy in Differentiating Tumefactive Demyelination from High-Grade Glioma?
  • Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions
  • Tumefactive demyelination associated with systemic lupus erythematosus
  • MR Imaging of Neoplastic Central Nervous System Lesions: Review and Recommendations for Current Practice
  • Tumefactive demyelination-to cracks the nut without cracking the pot
  • Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours
  • Dominant perivenular enhancement of tumefactive demyelinating lesions in multiple sclerosis
  • Imaging evaluation of demyelinating processes of the central nervous system
  • Tumefactive demyelinating lesions: a diagnostic challenge
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