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OtherPEDIATRICS

Leigh Syndrome with COX Deficiency and SURF1 Gene Mutations: MR Imaging Findings

Andrea Rossi, Roberta Biancheri, Claudio Bruno, Maja Di Rocco, Angela Calvi, Alice Pessagno and Paolo Tortori-Donati
American Journal of Neuroradiology June 2003, 24 (6) 1188-1191;
Andrea Rossi
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Roberta Biancheri
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Claudio Bruno
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Maja Di Rocco
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Angela Calvi
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Alice Pessagno
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Paolo Tortori-Donati
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Abstract

Summary: Mutations in the nuclear SURF1 gene are specifically associated with cytochrome c oxidase (COX)-deficient Leigh syndrome. MR imaging abnormalities in three children with this condition involved the subthalamic nuclei, medulla, inferior cerebellar peduncles, and substantia nigra in all cases. The dentate nuclei and central tegmental tracts were involved in two cases each (all instances), and the putamina, interpeduncular nucleus, and pallido-cortical-nigro-cortical tracts in one. MR imaging pattern recognition can suggest an underlying COX deficiency and should prompt investigators to search for SURF1 gene mutations.

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American Journal of Neuroradiology: 24 (6)
American Journal of Neuroradiology
Vol. 24, Issue 6
1 Jun 2003
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Leigh Syndrome with COX Deficiency and SURF1 Gene Mutations: MR Imaging Findings
Andrea Rossi, Roberta Biancheri, Claudio Bruno, Maja Di Rocco, Angela Calvi, Alice Pessagno, Paolo Tortori-Donati
American Journal of Neuroradiology Jun 2003, 24 (6) 1188-1191;

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Leigh Syndrome with COX Deficiency and SURF1 Gene Mutations: MR Imaging Findings
Andrea Rossi, Roberta Biancheri, Claudio Bruno, Maja Di Rocco, Angela Calvi, Alice Pessagno, Paolo Tortori-Donati
American Journal of Neuroradiology Jun 2003, 24 (6) 1188-1191;
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