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Research ArticleINTERVENTIONAL

Nidal Embolization of Brain Arteriovenous Malformations Using Onyx in 94 Patients

C. Mounayer, N. Hammami, M. Piotin, L. Spelle, G. Benndorf, I. Kessler and J. Moret
American Journal of Neuroradiology March 2007, 28 (3) 518-523;
C. Mounayer
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N. Hammami
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M. Piotin
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L. Spelle
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G. Benndorf
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I. Kessler
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J. Moret
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Article Figures & Data

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  • Fig 1.
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    Fig 1.

    Right posterior temporal BAVM treated in single-session procedure.

    A and B, Initial angiogram showing the nidus and the cortical drainage veins in anteroposterior (AP) and lateral views.

    C, Selective angiogram in AP view showing the microcatheterization with an intranidal position of the microcatheter tip (arrowhead), the nidal network (arrow), and one of the draining veins (white arrow).

    D and E, Nonsubtracted images in AP and lateral view showing the Onyx cast with some degree of reflux into the arterial feeder (arrow) and the draining vein filled by the embolic agent (white arrows).

    F and G, Final angiogram in AP and lateral views demonstrating the total occlusion of the BAVM.

  • Fig 2.
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    Fig 2.

    Large left frontal BAVM treated in staged sessions.

    A and B, Initial angiogram in anteroposterior (AP) and lateral views showing various arterial feeders allowing for nidal catheterization. To reduce periprocedural or postprocedural ischemic or hemorrhagic complications, the BAVM was gradually occluded in 3 sessions.

    C and D, Nonsubtracted images in AP and lateral views showing the extensive Onyx cast.

    E and F, Final angiographic control demonstrating total BAVM occlusion.

Tables

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    Table 1:

    Martin-Spetzler classification of brain arteriovenous malformations17

    GradePatients [% (n)]
    I4.5 (4)
    II37 (35)
    III40.5 (38)
    IV17 (16)
    V1 (1)
    Total100 (94)
    • View popup
    Table 2:

    Brain arteriovenous malformation locations

    Anatomic LocationsNo.
    Hemispheric
        Cortical
            Dominant hemisphere38
            Nondominant hemisphere35
        Deep
            Dominant hemisphere6
            Nondominant hemisphere4
    Corpus callosum2
    Cerebellum
        Vermis3
        Hemispheric4
    Quadrigeminal plate2
    Total94
    • View popup
    Table 3:

    Brain arteriovenous malformation nidus size

    Nidus SizePatients [% (n)]
    <2 cm13 (12)
    2–<4 cm48 (45)
    ≥4 cm39 (37)
    Total100 (94)
    • View popup
    Table 4:

    Permanent neurological treatment-related complications and death among the 94 patients

    Patient NoBAVM LocationsCausative AgentComplicationsComplication TypeOutcome (mRS)
    1Left subthalamusOnyxOphthalmoplegiaIschemic1
    2Quadrigeminal plateOnyx/n-BCATransient diplopiaHemorrhagic1
    3Right internal capsulen-BCALeft hemiparesisHemorrhagic3
    4Left frontal lobeOnyxTransient right hemiparesisHemorrhagic3
    5Right temporal loben-BCAHemianopsiaIschemic1
    6Right temporal loben-BCALeft hemiparesisHemorrhagic3
    7Right temporal loben-BCATransient left hemiparesisHemorrhagic3
    8Right temporal loben-BCALeft hemiparesisIschemic2
    9Right temporal lobeSurgeryDeathHemorrhagic6
    10Cerebellar vermisn-BCADeathHemorrhagic6
    11Left thalamusCatheterizationDeathHemorrhagic6
    Overall complications % (n)Neurologic complications12% (11)
    Deaths3% (3)
    Onyx-induced complications % (n)Neurologic complications3% (3)
    Deaths0 (0)
    • Note:—BAVM indicates brain arteriovenous malformation; mRS, modified Rankin scale; n-BCA, n-butyl cyanoacrylate

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American Journal of Neuroradiology: 28 (3)
American Journal of Neuroradiology
Vol. 28, Issue 3
March 2007
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Nidal Embolization of Brain Arteriovenous Malformations Using Onyx in 94 Patients
C. Mounayer, N. Hammami, M. Piotin, L. Spelle, G. Benndorf, I. Kessler, J. Moret
American Journal of Neuroradiology Mar 2007, 28 (3) 518-523;

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Nidal Embolization of Brain Arteriovenous Malformations Using Onyx in 94 Patients
C. Mounayer, N. Hammami, M. Piotin, L. Spelle, G. Benndorf, I. Kessler, J. Moret
American Journal of Neuroradiology Mar 2007, 28 (3) 518-523;
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  • Endovascular Treatment for Low-Grade (Spetzler-Martin I-II) Brain Arteriovenous Malformations
  • Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
  • Arterial embolization with Onyx of head and neck paragangliomas
  • Neurological outcomes and cure rates of embolization of brain arteriovenous malformations with n-butyl cyanoacrylate or Onyx: a meta-analysis
  • Multimodal angiographic assessment of cerebral arteriovenous malformations: a pilot study
  • Dual-Lumen Balloon Catheters May Improve Liquid Embolization of Vascular Malformations: An Experimental Study in Swine
  • Quantitative Assessment of Changes in Cerebral Arteriovenous Malformation Hemodynamics After Embolization
  • Endovascular treatment of unruptured and ruptured brain arteriovenous malformations with Onyx18: a monocentric series of 84 patients
  • Hemorrhagic Complications after Endovascular Treatment of Cerebral Arteriovenous Malformations
  • Transvenous Onyx embolization of a subependymal deep arteriovenous malformation with a single drainage vein: technical note
  • Transarterial balloon assisted Onyx embolization of pericallosal arteriovenous malformations
  • Transvenous Onyx embolization of a subependymal deep arteriovenous malformation with a single drainage vein: technical note
  • Reporting standards for angiographic evaluation and endovascular treatment of cerebral arteriovenous malformations
  • Over-the-catheter retrieval of a retained microcatheter following Onyx embolization: a technical report
  • The Use of Onyx in Different Types of Intracranial Dural Arteriovenous Fistula
  • Transarterial Treatment with Onyx of Intracranial Dural Arteriovenous Fistula with Cortical Drainage in 17 Patients
  • Safety and Clinical Efficacy of Onyx for Embolization of Extracranial Head and Neck Vascular Anomalies
  • Microsurgical retrieval of an endovascular microcatheter trapped during Onyx embolization of a cerebral arteriovenous malformation
  • Treatment of Brain Arteriovenous Malformations by Double Arterial Catheterization with Simultaneous Injection of Onyx: Retrospective Series of 17 Patients
  • Complete angiographic obliteration of intracranial AVMs with endovascular embolization: incomplete embolic nidal opacification is associated with AVM recurrence
  • Brain Arteriovenous Malformation Treatment Using a Combination of Onyx and a New Detachable Tip Microcatheter, SONIC: Short-Term Results
  • Provocative Test with Propofol: Experience in Patients with Cerebral Arteriovenous Malformations Who Underwent Neuroendovascular Procedures
  • The Use of Onyx for Embolization of Central Nervous System Arteriovenous Lesions in Pediatric Patients
  • Hemodynamic instability during treatment of intracranial dural arteriovenous fistula and carotid cavernous fistula with Onyx: preliminary results and anesthesia considerations
  • Adjuvant Embolization With N-Butyl Cyanoacrylate in the Treatment of Cerebral Arteriovenous Malformations: Outcomes, Complications, and Predictors of Neurologic Deficits
  • Preoperative Embolization of Cerebral Arteriovenous Malformations with Onyx
  • Embolization of Intracranial Arteriovenous Malformations with Ethylene-Vinyl Alcohol Copolymer (Onyx)
  • Embolization of Residual Fistula Following Stereotactic Radiosurgery in Cerebral Arteriovenous Malformations
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