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Research ArticleHEAD & NECK

Diagnostic Value of High-Resolution MR Imaging in Giant Cell Arteritis

T.A. Bley, M. Uhl, J. Carew, M. Markl, D. Schmidt, H.-H. Peter, M. Langer and O. Wieben
American Journal of Neuroradiology October 2007, 28 (9) 1722-1727; DOI: https://doi.org/10.3174/ajnr.A0638
T.A. Bley
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M. Uhl
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J. Carew
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M. Markl
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D. Schmidt
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H.-H. Peter
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M. Langer
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O. Wieben
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Abstract

BACKGROUND AND PURPOSE: Clinical indications of giant cell arteritis may be unspecific, and noninvasive diagnosis is often difficult. This study investigated the hypothesis that high-resolution MR imaging of the superficial cranial arteries is a noninvasive imaging technique that can detect the occurrence of giant cell arteritis.

MATERIALS AND METHODS: Contrast-enhanced, high-resolution MR imaging was performed on 64 consecutive patients with suspected giant cell arteritis. Mural thickness, lumen diameter, and a mural contrast enhancement score were assessed with T1-weighted spin-echo images with submillimeter in-plane spatial resolution. The final rheumatologist's diagnosis according to the clinical criteria of the American College of Rheumatology including laboratory tests and results of temporal artery biopsies from 32 patients was used as a “gold standard” for the evaluation of the MR imaging findings.

RESULTS: All of the examinations provided diagnostic image quality. Evaluation of the mural inflammatory MR imaging signs for diagnosing vasculitis resulted in a sensitivity of 80.6% and a specificity of 97.0%. In comparison, histology results alone showed a sensitivity of 77.8% and specificity of 100%. The mean wall thickness increased significantly from 0.39 mm (±0.18 mm) to 0.74 mm (±0.32 mm; P < .001), and the lumen diameter decreased significantly from 0.84 mm (±0.29 mm) to 0.65 mm (±0.38 mm; P < .05) for patients with giant cell arteritis.

CONCLUSION: Contrast-enhanced, high-resolution MR imaging allows noninvasive assessment of mural inflammation in giant cell arteritis with good diagnostic certainty. Measures of mural thickening and contrast enhancement can be obtained in these small vessels and provide valuable vasculitic MR imaging findings.

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American Journal of Neuroradiology: 28 (9)
American Journal of Neuroradiology
Vol. 28, Issue 9
October 2007
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Diagnostic Value of High-Resolution MR Imaging in Giant Cell Arteritis
T.A. Bley, M. Uhl, J. Carew, M. Markl, D. Schmidt, H.-H. Peter, M. Langer, O. Wieben
American Journal of Neuroradiology Oct 2007, 28 (9) 1722-1727; DOI: 10.3174/ajnr.A0638

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Diagnostic Value of High-Resolution MR Imaging in Giant Cell Arteritis
T.A. Bley, M. Uhl, J. Carew, M. Markl, D. Schmidt, H.-H. Peter, M. Langer, O. Wieben
American Journal of Neuroradiology Oct 2007, 28 (9) 1722-1727; DOI: 10.3174/ajnr.A0638
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  • Imaging in diagnosis, outcome prediction and monitoring of large vessel vasculitis: a systematic literature review and meta-analysis informing the EULAR recommendations
  • Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease
  • 3T MRI Reveals Extra- and Intracranial Involvement in Giant Cell Arteritis
  • Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques
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  • Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques
  • Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion
  • High-resolution MRI for assessment of middle meningeal artery involvement in giant cell arteritis
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