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Case ReportBrain

Ipilimumab-Induced Hypophysitis: MR Imaging Findings

K.J. Carpenter, R.D. Murtagh, H. Lilienfeld, J. Weber and F.R. Murtagh
American Journal of Neuroradiology October 2009, 30 (9) 1751-1753; DOI: https://doi.org/10.3174/ajnr.A1623
K.J. Carpenter
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R.D. Murtagh
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H. Lilienfeld
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J. Weber
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F.R. Murtagh
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Abstract

SUMMARY: Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.

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American Journal of Neuroradiology: 30 (9)
American Journal of Neuroradiology
Vol. 30, Issue 9
1 Oct 2009
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Ipilimumab-Induced Hypophysitis: MR Imaging Findings
K.J. Carpenter, R.D. Murtagh, H. Lilienfeld, J. Weber, F.R. Murtagh
American Journal of Neuroradiology Oct 2009, 30 (9) 1751-1753; DOI: 10.3174/ajnr.A1623

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Ipilimumab-Induced Hypophysitis: MR Imaging Findings
K.J. Carpenter, R.D. Murtagh, H. Lilienfeld, J. Weber, F.R. Murtagh
American Journal of Neuroradiology Oct 2009, 30 (9) 1751-1753; DOI: 10.3174/ajnr.A1623
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  • MRI Findings of Immune Checkpoint Inhibitor-Induced Hypophysitis: Possible Association with Fibrosis
  • Adrenal Insufficiency Related to Anti-Programmed Death-1 Therapy
  • Ipilimumab Therapy for Melanoma: A Mimic of Leptomeningeal Metastases
  • Long-term follow-up of ipilimumab-induced hypophysitis, a common adverse event of the anti-CTLA-4 antibody in melanoma
  • ENDOCRINE SIDE-EFFECTS OF ANTI-CANCER DRUGS: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses
  • Neurological immune-related adverse events of ipilimumab
  • Ipilimumab and Its Toxicities: A Multidisciplinary Approach
  • MECHANISMS IN ENDOCRINOLOGY: Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review
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